POLK Products
(Polymerase (DNA Directed) kappa (POLK))
Categories
External and internal DNA-damaging agents continually threaten the integrity of genetic material in cells. Although a variety of repair mechanisms exist to remove the resulting lesions, some lesions escape repair and block the replication machinery. Members of the Y family of DNA polymerases, such as POLK, permit the continuity of the replication fork by allowing replication through such DNA lesions. Each Y family polymerase has a unique DNA-damage bypass and fidelity profile. POLK is specialized for the extension step of lesion bypass (summary by Lone et al., 2007 [PubMed 17317631]).[supplied by OMIM, Jan 2010].
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Featured POLK Categories
POLK Antibodies
High quality antibodies with extensive validation data.
POLK Proteins
Proteins for various applications incl. WB, ELISA, IF etc.
Recommended POLK Antibodies
Product
Reactivity
Application
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Application
WB, ELISA, IF, IHC (p), RNAi
Validations
- (1)
- (7)
Cat. No.
ABIN565606
Quantity
100 μg
Datasheet
Datasheet
Reactivity
Human
Application
WB, IF
Validations
- (3)
Cat. No.
ABIN949322
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human, Mouse, Rat
Application
IF
Validations
- (2)
Cat. No.
ABIN7261966
Quantity
200 μL
Datasheet
Datasheet
Recommended POLK ELISA Kits
Product
Reactivity
Analytical Method
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
Cat. No.
ABIN6206770
Quantity
96 tests
Datasheet
Datasheet
Recommended POLK Proteins
Product
Reactivity
Source
Validations
Cat. No.
Quantity
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (3)
- (3)
Cat. No.
ABIN2452172
Quantity
50 μg
Datasheet
Datasheet
Reactivity
Human
Source
Wheat germ
Validations
- (1)
Cat. No.
ABIN1315652
Quantity
10 μg
Datasheet
Datasheet
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
Cat. No.
ABIN7124513
Quantity
50 μg
Datasheet
Datasheet
Latest Publications for our POLK products
: "RNA m6A methylation regulates the ultraviolet-induced DNA damage response." in: Nature, Vol. 543, Issue 7646, pp. 573-576, (2017) (PubMed).: "Both high-fidelity replicative and low-fidelity Y-family polymerases are involved in DNA rereplication." in: Molecular and cellular biology, Vol. 35, Issue 4, pp. 699-715, (2015) (PubMed).
: "Crystal structure of the catalytic core of human DNA polymerase kappa." in: Structure (London, England : 1993), Vol. 12, Issue 8, pp. 1395-404, (2004) (PubMed).
: "Translesion synthesis past 2'-deoxyxanthosine, a nitric oxide-derived DNA adduct, by mammalian DNA polymerases." in: Journal of molecular biology, Vol. 344, Issue 3, pp. 665-74, (2004) (PubMed).
: "A mechanism for the exclusion of low-fidelity human Y-family DNA polymerases from base excision repair." in: Genes & development, Vol. 17, Issue 22, pp. 2777-85, (2003) (PubMed).
: "Fidelity and processivity of DNA synthesis by DNA polymerase kappa, the product of the human DINB1 gene." in: The Journal of biological chemistry, Vol. 275, Issue 50, pp. 39678-84, (2001) (PubMed).
: "Error-prone bypass of certain DNA lesions by the human DNA polymerase kappa." in: Genes & development, Vol. 14, Issue 13, pp. 1589-94, (2000) (PubMed).
: "The metabolism of oleic, linoleic and linolenic acids by sheep with reference to their effects on methane production." in: The British journal of nutrition, Vol. 20, Issue 2, pp. 349-62 (PubMed).
Synonyms and alternative names related to POLK
DNA polymerase kappa (POLK), DNA polymerase kappa (Polk), polymerase (DNA directed) kappa (polk), DNA polymerase kappa (Tb11.01.0080), DNA polymerase kappa (Tb11.01.0010), DNA polymerase kappa (Tb11.01.0020), DNA polymerase kappa (Tb11.01.0030), DNA polymerase kappa (Tb11.01.0040), DNA polymerase kappa (Tb11.01.0050), DNA polymerase kappa (Tb11.12.0001), DNA polymerase kappa (Tb11.12.0002), DNA polymerase kappa (Tb11.12.0003), polymerase (DNA directed), kappa (Polk), polymerase (DNA directed) kappa L homeolog (polk.L), DNA polymerase kappa (polk-1), DINB1, Dinb1, DINP, POLK, POLQ, si:ch211-254o18.3Protein level used designations for POLK
- DNA polymerase kappa
- DNA-directed DNA polymerase kappa
- polymerase (DNA directed) kappa
- DNA polymerase kappa-like
- DINB protein
- DINP
- DNA damage-inducible protein b
- DinB homolog 1
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