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anti-Human MCU Antibodies:
anti-Mouse (Murine) MCU Antibodies:
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Human Polyclonal MCU Primary Antibody for ICC, IF - ABIN4288500
Baughman, Perocchi, Girgis, Plovanich, Belcher-Timme, Sancak, Bao, Strittmatter, Goldberger, Bogorad, Koteliansky, Mootha: Integrative genomics identifies MCU as an essential component of the mitochondrial calcium uniporter. in Nature 2011
Show all 8 Pubmed References
MICU1 (show MICU1 Antibodies) imparts the mitochondrial uniporter with the ability to discriminate between Ca(2 (show CA2 Antibodies)+) and Mn(2+).
Mitochondrial Ca(2 (show CA2 Antibodies)+) uptake is controlled by protein arginine methyl transferase 1 that asymmetrically methylates MICU1 (show MICU1 Antibodies), resulting in decreased Ca(2 (show CA2 Antibodies)+) sensitivity. UCP2 (show UCP2 Antibodies)/3 normalize Ca(2 (show CA2 Antibodies)+) sensitivity of methylated MICU1 (show MICU1 Antibodies) and, thus, re-establish mitochondrial Ca(2 (show CA2 Antibodies)+) uptake activity.
VDAC1 (show VDAC1 Antibodies) allows Ca(2 (show CA2 Antibodies)+) access to the MCU, facilitating transport of Ca(2 (show CA2 Antibodies)+) to the matrix, and also from the IMS to the cytosol. Intra-mitochondrial Ca(2 (show CA2 Antibodies)+) controls energy production and metabolism by modulating critical enzymes in the tricarboxylic acid (TCA) cycle and fatty acid oxidation.
MICU2 restricts spatial crosstalk between InsP3R (show ITPR1 Antibodies) and MCU channels by regulating threshold and gain of MICU1 (show MICU1 Antibodies)-mediated inhibition and activation of MCU.
The results highlight the dynamic nature of uniporter subunit assembly, which must be tightly regulated to ensure proper mitochondrial responses to intracellular Ca(2 (show CA2 Antibodies)+) signals.
MCU expression returned to physiological levels in visceral adipose tissue of patients after weight loss by bariatric surgery. Altered mitochondrial calcium flux in fat cells may play a role in obesity and diabetes and may be associated with the differential metabolic profiles of visceral and subcutaneous adipose tissue.
Mitochondrial calcium uniporter plays an important role in hyperglycaemia-induced endothelial cell dysfunction.
The studies findings in aging human skeletal muscle confirm the data obtained in mice and propose mitochondrial calcium uniporter and mitochondria-related proteins as potential pharmacological targets to counteract age-related muscle loss.
decreased MCU expression in hypertensive with mutation cells contributed to dysregulated Ca(2 (show CA2 Antibodies)+) uptake into the mitochondria
The molecular structure and regulation of the MCU complex in addition to its pathophysiological role are discussed with particular attention to striated (show NSDHL Antibodies) muscle tissues. Review.
the endothelial barrier was preserved in respiratory epithelium isolated from MCU-/- mice after exposure to IL-13 (show IL13 Antibodies). In the ovalbumin (show OVA Antibodies)-model of allergic airway disease, MCU deficiency resulted in decreased apoptosis within the large airway epithelial cells. Concordantly, expression of the tight junction protein ZO-1 (show TJP1 Antibodies) was preserved, indicative of maintenance of epithelial barrier function
Results suggest that inhibition of MCU attenuates Abeta (show APP Antibodies)-induced mcroglial apoptosis, and that it does so through modulation of reactive oxygen species-mediated endoplasmic reticulum stress. Understanding the apparent links between endoplasmic reticulum stress, oxidative stress and MCU could lead to the development of therapeutic strategies targeting Abeta (show APP Antibodies)-mediated microglial death.
These data indicate that Ca(2 (show CA2 Antibodies)+) uptake via mitochondrial uniporter contributes to palmitic acid-induced apoptosis in mouse podocytes.
a possible role for tissue-specific stoichiometry between the Ca(2 (show CA2 Antibodies)+)-sensing regulators (MICUs) and pore unit (MCU) of the uniporter, was investigated.
MCUR1 binds to MCU and EMRE and function as a scaffold factor.
MCU and EMRE proteins were mainly targeting to the IMM-outer mitochondrial membrane.
Regulation of mitochondrial Ca(2 (show CA2 Antibodies)+) suggests that MCU may play a pivotal role in the development of fibrosis and could potentially be a therapeutic target for pulmonary fibrosis.
Reveal a distinct functional role for Cys (show DNAJC5 Antibodies)-97 in mitochondrial reactive oxygen species sensing and regulation of MCU activity.
The m-AAA (show AAAS Antibodies) protease associated with neurodegeneration limits MCU activity in mitochondria.
This gene encodes a calcium transporter that localizes to the mitochondrial inner membrane. The encoded protein interacts with mitochondrial calcium uptake 1. Alternative splicing results in multiple transcript variants.
calcium uniporter protein, mitochondrial
, coiled-coil domain-containing protein 109A
, coiled-coil domain containing 109A