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In male breast cancer patients high forkhead box protein M1 (FOXM) expression is significantly associated with disease free survival (DFS (show FST Proteins)). Median progression free survival under chemotherapy or Tamoxifen hormone therapy is shorter for the High FOXM1 expression group. High FOXM1 expression is significantly associated with chemotherapy and endocrine resistance.
High FoxM1 expression is associated with the development of prostate cancer.
FOXM1 promotes proliferation in human hepatocellular carcinoma cells by transcriptional activation of CCNB1 (show CCNB1 Proteins).
Upregulation of FOXM1 in a subset of relapsed myeloma results in poor outcome.
We first reported that the FOMX1 pathway is the most upregulated and the PPARalpha (show PPARA Proteins) pathway is the most downregulated pathway in Triple Negative Breast Cancers (TNBCs). These two pathways could be simultaneously targeted in further studies. Also the pathway classifier we performed in this study provided insight into the TNBC heterogeneity.
FOXM1 and ABCG2 may be useful targets and important parameters in the treatment of bladder cancer.
FOXM1 is a highly prognostic marker for disease progression.
Study found that FOXM1 is a target of miR (show MLXIP Proteins)-149. miR (show MLXIP Proteins)-149 inhibited FOXM1 mRNA and protein expression levels by binding to its 3'-UTR in non-small cell lung cancer (NSCLC) cells. Moreover, patients with low expression levels of miR (show MLXIP Proteins)-149 exerted high FOXM1 mRNA levels.
we found that FOXM1 inhibitor attenuated tumorigenesis and radioresistance of glioblastoma (GBM) both in vitro and in vivo. Altogether, BUB1B (show BUB1B Proteins) promotes tumor proliferation and induces radioresistance in GBM, indicating that BUB1B (show BUB1B Proteins) could be a potential therapeutic target for GBM.
MYBL2 (show MYBL2 Proteins) is a key downstream factor of Akt (show AKT1 Proteins)/FoxM1 signaling to promote progression of human glioma, and could be a new candidate gene for molecular targeting therapy and biomarker for radiotherapy of glioma.
Disrupting LXRalpha (show NR1H3 Proteins) phosphorylation promotes FoxM1 expression and modulates atherosclerosis by inducing macrophage proliferation
Upregulated ROS (show ROS1 Proteins) induced by FABP4 (show FABP4 Proteins) was of significance in activating FoxM1 leading to airway inflammation and epithelial barrier dysfunction.
Interactions between the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) and the Kras/ERK (show EPHB2 Proteins)/Foxm1 pathways are essential to restrict SOX9 (show SOX9 Proteins) expression in basal cells during pulmonary branching morphogenesis
YAP (show YAP1 Proteins) cooperates with FOXM1 to contribute to chromosome instability in hepatocellular carcinoma.
RCM-1 (show TNNI3 Proteins) blocked the nuclear localization and increased the proteasomal degradation of Forkhead box M1 (FOXM1), a transcription factor critical for the differentiation of goblet cells from airway progenitor cells.
These data implicate the insulin (show INS Proteins)-FoxM1/PLK1/CENP-A (show CENPA Proteins) pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.
EGF (show EGF Proteins) promotes FoxM1 expression through the ERK (show EPHB2 Proteins) signal pathway
FoxM1 induction in the pulmonary vasculature was inhibited by a p110gamma (show PIK3CG Proteins)-selective inhibitor and in Pik3cg (show PIK3CG Proteins)(-/-) mice after LPS (show TLR4 Proteins) challenge. Defective vascular repair in Pik3cg (show PIK3CG Proteins)-/- mice results from impaired FoxM1 expression
we suggest that proper regional decidualization and polyploidy development requires FoxM1 signaling downstream of Hoxa10 (show HOXA10 Proteins) and cyclin D3 (show CCND3 Proteins).
FOXM1 and CENPF (show CENPF Proteins) are master regulators of prostate cancer malignancy, and can serve as drug response markers for antineoplastic drugs efficiency.
the sequence and expression pattern of FoxM1 (fork head box M1) transcription factor in Xenopus laevis embryos are described
Results suggest that FoxM1 functions to link cell division and neuronal differentiation in early Xenopus embryos.
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene.
Forkhead, drosophila, homolog-like 16
, HNF-3/fork-head homolog 11
, M-phase phosphoprotein 2
, MPM-2 reactive phosphoprotein 2
, forkhead box protein M1
, forkhead-related protein FKHL16
, hepatocyte nuclear factor 3 forkhead homolog 11
, transcription factor Trident
, winged-helix factor from INS-1 cells
, INS-1 winged helix
, forkhead box M1
, forkhead box protein M1-like
, forkhead homolog 16
, winged-helix transcription factor Trident