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NF-kappaB (show NFKB1 Proteins) physically interacts with FOXM1 and promotes transcription of FOXM1 gene. NF-kappaB (show NFKB1 Proteins) directly binds FOXM1 gene promoter. Silencing p65 (show GORASP1 Proteins) attenuates FOXM1 and beta-catenin (show CTNNB1 Proteins) expression. NF-kappaB (show NFKB1 Proteins) activation is required for nuclear translocation of FOXM1 and beta-catenin (show CTNNB1 Proteins). FOXM1 and beta-catenin (show CTNNB1 Proteins) positively regulate NF-kappaB.Knockdown of beta-catenin (show CTNNB1 Proteins) and FOXM1 downregulates p65 (show GORASP1 Proteins) protein and NF-kappaB (show NFKB1 Proteins)-dependent reporte...
FOXM1 expression in solid tumor tissues is associated with poor survival in most solid tumors, which suggests that FOXM1 is a valuable prognostic biomarker and a promising therapeutic target for solid tumors.
FOXM1 is up-regulated in all three major EOCs subtypes, and is a prognostic biomarker and a potential combinatorial therapeutic target in platinum resistant disease, irrespective of tumor histology.
Authors demonstrated that inhibition of either FOXM1 or AGR2 (show AGR2 Proteins) in human PIMAs inhibited mucinous characteristics, and reduced tumor growth and invasion. FOXM1 is necessary and sufficient to induce mucinous phenotypes in lung tumor cells in vivo.
we hypothesize that FOXM1 regulates radioresistance via STAT3 (show STAT3 Proteins) in GBM cells. We also, show GBM patients with high FOXM1 expression have poor prognosis.
FOXM1 promotes 5-FU resistance by up-regulating ABCC10 (show ABCC10 Proteins) expression in colorectal tumor cells.
Findings provide a novel understanding of the mechanism of gastric cancer and highlight the important role of BTF3 (show BTF3 Proteins)/FOXM1 in tumor growth and BTF3 (show BTF3 Proteins)/JAK2 (show JAK2 Proteins)/STAT3 (show STAT3 Proteins) in EMT (show ITK Proteins) and metastasis
FOXM1 bound directly to the GLUT1 (show SLC2A1 Proteins) and HK2 (show HK2 Proteins) promoter regions and regulated the promoter activities and the expression of the genes at the transcriptional level. This reveals a novel mechanism by which glucose metabolism is regulated by FOXM1.
Gli1 (show GLI1 Proteins) promotes colorectal cancer cells metastasis in a Foxm1-dependent manner by activating EMT (show ITK Proteins) and PI3K (show PIK3CA Proteins)-AKT (show AKT1 Proteins) signaling.
we suggest that high glucose and elevated O-GlcNAcylation stabilize FOXM1 protein by its reduced degradation via GSK-3beta inactivation in MKN45 cells, suggesting that the higher risk of gastric cancer in diabetic patients could be partially due to O-GlcNAcylation-mediated FOXM1 stabilization
Upregulated ROS (show ROS1 Proteins) induced by FABP4 (show FABP4 Proteins) was of significance in activating FoxM1 leading to airway inflammation and epithelial barrier dysfunction.
Interactions between the Wnt (show WNT2 Proteins)/beta-catenin (show CTNNB1 Proteins) and the Kras/ERK (show EPHB2 Proteins)/Foxm1 pathways are essential to restrict SOX9 (show SOX9 Proteins) expression in basal cells during pulmonary branching morphogenesis
YAP (show YAP1 Proteins) cooperates with FOXM1 to contribute to chromosome instability in hepatocellular carcinoma.
RCM-1 (show TNNI3 Proteins) blocked the nuclear localization and increased the proteasomal degradation of Forkhead box M1 (FOXM1), a transcription factor critical for the differentiation of goblet cells from airway progenitor cells.
These data implicate the insulin (show INS Proteins)-FoxM1/PLK1/CENP-A (show CENPA Proteins) pathway-regulated mitotic cell-cycle progression as an essential component in the beta cell adaptation to delay and/or prevent progression to diabetes.
EGF (show EGF Proteins) promotes FoxM1 expression through the ERK (show EPHB2 Proteins) signal pathway
FoxM1 induction in the pulmonary vasculature was inhibited by a p110gamma (show PIK3CG Proteins)-selective inhibitor and in Pik3cg (show PIK3CG Proteins)(-/-) mice after LPS (show TLR4 Proteins) challenge. Defective vascular repair in Pik3cg (show PIK3CG Proteins)-/- mice results from impaired FoxM1 expression
we suggest that proper regional decidualization and polyploidy development requires FoxM1 signaling downstream of Hoxa10 (show HOXA10 Proteins) and cyclin D3 (show CCND3 Proteins).
FOXM1 and CENPF (show CENPF Proteins) are master regulators of prostate cancer malignancy, and can serve as drug response markers for antineoplastic drugs efficiency.
Both gain-of-function and loss-of-function TP53 (show TP53 Proteins) mutations contribute to overexpression of FoxM1 in high-grade serous ovarian cancer.
the sequence and expression pattern of FoxM1 (fork head box M1) transcription factor in Xenopus laevis embryos are described
Results suggest that FoxM1 functions to link cell division and neuronal differentiation in early Xenopus embryos.
The protein encoded by this gene is a transcriptional activator involved in cell proliferation. The encoded protein is phosphorylated in M phase and regulates the expression of several cell cycle genes, such as cyclin B1 and cyclin D1. Several transcript variants encoding different isoforms have been found for this gene.
forkhead box protein M1
, forkhead box M1
, forkhead box protein M1-like
, Forkhead, drosophila, homolog-like 16
, HNF-3/fork-head homolog 11
, M-phase phosphoprotein 2
, MPM-2 reactive phosphoprotein 2
, forkhead-related protein FKHL16
, hepatocyte nuclear factor 3 forkhead homolog 11
, transcription factor Trident
, winged-helix factor from INS-1 cells
, forkhead homolog 16
, winged-helix transcription factor Trident
, INS-1 winged helix