The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein has been shown to possess PPIase activity and, similar to other family members, can bind to the immunosuppressant cyclosporin A. [provided by RefSeq, Jul 2008].
Nguyen, Stevens, Kohr, Steenbergen, Sack, Murphy: "Cysteine 203 of cyclophilin D is critical for cyclophilin D activation of the mitochondrial permeability transition pore." in: The Journal of biological chemistry, Vol. 286, Issue 46, pp. 40184-92, (2011) (PubMed).
McGee, Baines: "Complement 1q-binding protein inhibits the mitochondrial permeability transition pore and protects against oxidative stress-induced death." in: The Biochemical journal, Vol. 433, Issue 1, pp. 119-25, (2010) (PubMed).
Aliases for PPID Proteins
peptidylprolyl isomerase D (PPID) Proteins peptidylprolyl isomerase D (Ppid) Proteins peptidylprolyl isomerase D (ppid) Proteins peptidylprolyl isomerase D (cyclophilin D) (Ppid) Proteins peptidylprolyl isomerase D (cyclophilin D) S homeolog (ppid.S) Proteins 4930564J03Rik Proteins CYP-40 Proteins Cyp-40 Proteins cyp-40 Proteins CYPD Proteins CypD Proteins cypd Proteins PPID Proteins Ppidl Proteins Ppif Proteins wu:fb18b07 Proteins zgc:86711 Proteins