ULBP2 Protein (AA 26-217) (His tag)

Catalog No. ABIN1097760

This Recombinant ULBP2 protein is produced in Human Cells.

Quick Overview for ULBP2 Protein (AA 26-217) (His tag) (ABIN1097760)

Target: ULBP2 (UL16 Binding Protein 2 (ULBP2))

Protein Type: Recombinant

Origin: Human

Source: Human Cells

Purity: > 95 % as determined by reducing SDS-PAGE.

Product Details

Protein Characteristics: AA 26-217

Purification tag / Conjugate: This ULBP2 protein is labelled with His tag.

Purpose: Recombinant Human NKG2D Ligand 2/NKG2DL2/N2DL2 (C-6His)

Sequence: GRADPHSLCY DITVIPKFRP GPRWCAVQGQ VDEKTFLHYD CGNKTVTPVS PLGKKLNVTT AWKAQNPVLR EVVDILTEQL RDIQLENYTP KEPLTLQARM SCEQKAEGHS SGSWQFSFDG QIFLLFDSEK RMWTTVHPGA RKMKEKWEND KVVAMSFHYF SMGDCIGWLE DFLMGMDSTL EPSAGAPLAM SSVDHHHHHH

Characteristics:

Recombinant Human NKG2D Ligand 2/NKG2DL2/N2DL2 (C-6His)

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.2.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: ULBP2 (UL16 Binding Protein 2 (ULBP2))

Alternative Name: NKG2D Ligand 2/N2DL2

Background: Recombinant Human NKG2D Ligand 2/N2DL2 produced by transfected human cells is a secreted protein with sequence (Gly26-Ser216) of Human N2DL2 fused with a polyhistidine tag at the C-terminus.
NKG2D Ligand 2 (N2DL2) is a member of a family of cell-surface proteins. N2DL2 function as ligands for human cytomegalovirus glycoprotein UL16. N2DL2 is anchored to the membrane via a GPI-linkage. N2DL2 is bind to human NKG2D, an activating receptor expressed on NK cells, NKT cells, T cells. Engagement of NKG2D results in the activation of cytolytic activity and cytokine production by these effects cells. The ULBPs are expressed on some tumor cells and have been implicated in tumor surveillance.

Molecular Weight: 22.78 kDa

UniProt: Q9BZM5