TNFRSF4 Protein (AA 29-214) (Fc Tag)
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- Target See all TNFRSF4 Proteins
- TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 29-214
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Origin
- Human, Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This TNFRSF4 protein is labelled with Fc Tag.
- Application
- SDS-PAGE (SDS)
- Specificity
- Binds to human and mouse OX40L.
- Cross-Reactivity
- Human, Mouse (Murine)
- Characteristics
- Human OX40 (aa 29-214) is fused at the C-terminus to the Fc portion of human IgG1.
- Purity
- >95 % (SDS-PAGE)
- Endotoxin Level
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product TNFRSF4 Protein
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Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 20-211) protein (His-Avi Tag)
TNFRSF4 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 92 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 20-211) protein (His-Avi Tag,Biotin)TNFRSF4 Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 29-216) (Active) protein (Fc Tag)TNFRSF4 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 29-216) (Active) protein (His tag)TNFRSF4 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 29-216) protein (Fc Tag)TNFRSF4 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE
Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 29-216) protein (His-Avi Tag)TNFRSF4 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) protein (His-Avi Tag,Biotin)TNFRSF4 Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 29-214) (Active) protein (His tag)TNFRSF4 Origin: Marmoset Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (AA 29-216) (Active) protein (His tag,AVI tag,Biotin)TNFRSF4 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4) (Active) protein (His tag)TNFRSF4 Origin: Mouse Host: Human Cells Recombinant > 95 % as determined by SDS-PAGE Active
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Blocks T cell proliferation induced by CD134L.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute with 50 μL sterile water.
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Expiry Date
- 6 months
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- Target
- TNFRSF4 (Tumor Necrosis Factor Receptor Superfamily, Member 4 (TNFRSF4))
- Alternative Name
- OX40 (TNFRSF4 Products)
- Synonyms
- TNFRSF4 Protein, ACT35 Protein, CD134 Protein, Ly-70 Protein, Ox40 Protein, TXGP1L Protein, Txgp1 Protein, OX40 Protein, TNF receptor superfamily member 4 Protein, tumor necrosis factor receptor superfamily, member 4 Protein, TNFRSF4 Protein, Tnfrsf4 Protein
- Background
- OX40 binds to receptors on T-cells, preventing them from dying and subsequently increasing cytokine production. OX40 has a critical role in the maintenance of an immune response. OX40:Fc was shown to prevent OX40 from reaching the T-cell receptors, thus reducing the T-cell response. Experiments in mice have demonstrated that OX40:Fc can reduce the symptoms associated with the cytokine storm (an immune overreaction) while allowing the immune system to fight off the virus successfully.
- Molecular Weight
- ~70kDa (SDS-PAGE)
- UniProt
- P43489
- Pathways
- Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints
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