TNFRSF10A Protein (AA 24-239, Extracellular Domain) (Fc Tag)
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- Target See all TNFRSF10A Proteins
- TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- Extracellular Domain, AA 24-239
- Origin
- Human, Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This TNFRSF10A protein is labelled with Fc Tag.
- Application
- SDS-PAGE (SDS)
- Specificity
- Binds to human and mouse TRAIL.
- Cross-Reactivity
- Human, Mouse (Murine)
- Characteristics
- The extracellular domain of human TRAIL-R1 (aa 24-239) is fused to the Fc portion of human IgG1.
- Purity
- >95 % (SDS-PAGE)
- Endotoxin Level
- <0.01EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product TNFRSF10A Protein
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Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) protein (His-Avi Tag,Biotin)
TNFRSF10A Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) (AA 34-239) protein (Fc Tag)TNFRSF10A Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) protein (His-Avi Tag)TNFRSF10A Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) (AA 103-239) protein (His-DYKDDDDK-Strep II Tag)TNFRSF10A Origin: Human Host: HEK-293T Cells Recombinant SDS, WB, ELISA, PI
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) (AA 24-239) protein (Fc Tag)TNFRSF10A Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE.
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) protein (His tag)TNFRSF10A Origin: Human Host: Human Cells Recombinant >95 % as determined by reducing SDS-PAGE.
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) (AA 379-445) protein (His-IF2DI Tag)TNFRSF10A Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) (AA 105-204) protein (GST tag)TNFRSF10A Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) (AA 1-238) proteinTNFRSF10A Origin: Human Host: Human Recombinant SDS
Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A) (AA 24-239) protein (His tag)Crystallography grade TNFRSF10A Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Blocks human or mouse TRAIL activity in a concentration of 1-10μg/ml.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute with 50 μL sterile water.
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Expiry Date
- 6 months
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- Target
- TNFRSF10A (Tumor Necrosis Factor Receptor Superfamily, Member 10a (TNFRSF10A))
- Alternative Name
- TRAIL-R1 (TNFRSF10A Products)
- Synonyms
- APO2 Protein, CD261 Protein, DR4 Protein, TRAILR-1 Protein, TRAILR1 Protein, TNFRSF10A Protein, TNF receptor superfamily member 10a Protein, tumor necrosis factor receptor superfamily member 26 Protein, tumor necrosis factor receptor superfamily, member 10a Protein, TNFRSF10A Protein, LOC510798 Protein
- Background
- TRAIL-R1 (DR4, CD261) is a receptor for the cytotoxic ligand TRAIL. The adapter molecule FADD recruits caspase-8 to the activated receptor. The resulting death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation which initiates the subsequent cascade of caspases (aspartate-specific cysteine proteases) mediating apoptosis. Promotes the activation of NF-kappaB.
- Molecular Weight
- ~52kDa (SDS-PAGE)
- UniProt
- O00220
- Pathways
- Apoptosis, Positive Regulation of Endopeptidase Activity
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