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IFN alpha 2b Protein

Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE
Catalog No. ABIN1880391
  • Target See all IFN alpha 2b products
    IFN alpha 2b
    Protein Type
    Recombinant
    Origin
    Human
    Source
    • 2
    • 1
    • 1
    Escherichia coli (E. coli)
    Purity
    > 95 % by SDS-PAGE
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstitute with sterile 18 mΩ/cm^3 H2O.
    Buffer
    10 mM Phosphate buffer and 200 mM NaCl (pH 7.0)
    Preservative
    Without preservative
    Storage
    4 °C
  • Target
    IFN alpha 2b
    Abstract
    IFN alpha 2b Products
    Synonyms
    IFN-alphaA Protein, IFNA Protein, IFNA2B Protein, INFA2 Protein, interferon alpha 2 Protein, IFNA2 Protein
    Background
    IFN-alpha, a multifunctional cytokine important in the innate immune system, has been proposed to play a major pathogenic role in the development of systemic lupus erythematosus in humans and mice. IFNA bound complement component receptor-2 (CR2) in the same affinity range as other CR2 ligands. Asokan et al. (2006) proposed that the roles of CR2 and IFNA in development of autoimmunity may be mechanistically linked to pathogenesis of systemic lupus erythematosus. Interferon-alpha and -beta (IFN-alpha/beta) and the tumour suppressor p53 are essential for the induction of apoptosis in cancerous cells and in antiviral immune responses, respectively. The transcription of the p53 gene is induced by IFN-alpha/beta, accompanied by an increase in p53 protein level. IFN-alpha/beta signalling itself does not activate p53, rather, it contributes to boosting p53 responses to stress signals.
    Molecular Weight
    19.2 +/- 1.9 kDa
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