IL12 Protein
Quick Overview for IL12 Protein (ABIN1880414)
Target
See all IL12 ProteinsProtein Type
Origin
Source
Purity
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstitute with sterile 18 mΩ/cm^3 H2O.
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Buffer
- 10 mM Phosphate buffer and 200 mM NaCl (pH 7.0)
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Preservative
- Without preservative
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Storage
- 4 °C
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- IL12 (Interleukin 12 (IL12))
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Alternative Name
- IL-12
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Background
- Interleukin 12 (IL-12) is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation. IL-12 is composed of a bundle of four alpha helices. It is a heterodimeric cytokine encoded by two separate genes, IL-12A (p35) and IL-12B (p40). The active heterodimer, and a homodimer of p40 are formed following protein synthesis. It plays a critical role in modulating the activities of natural killer (NK) cells and T lymphocytes. In animal models, IL-12 has potent antitumor effects that are likely mediated by its ability to enhance the cytotoxic activity of NK cells and cytotoxic T lymphocytes, and to induce the production of interferon (IFN)-gamma by NK and T cells.
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Molecular Weight
- 75 kDa
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Pathways
- JAK-STAT Signaling, TLR Signaling, Cellular Response to Molecule of Bacterial Origin, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Activated T Cell Proliferation, Cancer Immune Checkpoints, Inflammasome
Target
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