NrCAM Protein (AA 25-600) (Fc Tag)

Catalog No. ABIN1880634

Product Details

Target: NrCAM (NRCAM) (Neuronal Cell Adhesion Molecule (NRCAM))

Protein Type: Recombinant

Protein Characteristics: AA 25-600

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This NrCAM protein is labelled with Fc Tag.

Purpose: Recombinant Human Neuronal Cell Adhesion Molecule/NRCAM (C-Fc)

Sequence: QMISALEVPL DPKLLEDLVQ PPTITQQSPK DYIIDPRENI VIQCEAKGKP PPSFSWTRNG THFDIDKDPL VTMKPGTGTL IINIMSEGKA ETYEGVYQCT ARNERGAAVS NNIVVRPSRS PLWTKEKLEP ITLQSGQSLV LPCRPPIGLP PPIIFWMDNS FQRLPQSERV SQGLNGDLYF SNVLPEDTRE DYICYARFNH TQTIQQKQPI SVKVISAKSS RERPPTFLTP EGNASNKEEL RGNVLSLECI AEGLPTPIIY WAKEDGMLPK NRTVYKNFEK TLQIIHVSEA DSGNYQCIAK NALGAIHHTI SVRVKAAPYW ITAPQNLVLS PGEDGTLICR ANGNPKPRIS WLTNGVPIEI APDDPSRKID GDTIIFSNVQ ERSSAVYQCN ASNEYGYLLA NAFVNVLAEP PRILTPANTL YQVIANRPAL LDCAFFGSPL PTIEWFKGAK GSALHEDIYV LHENGTLEIP VAQKDSTGTY TCVARNKLGM AKNEVHLEIK DATWIVKQPE YAVVQRGSMV SFECKVKHDH TLSLTVLWLK DNRELPSDER FTVDKDHLVV ADVSDDDSGT YTCVANVDDI EGRMDEPKSC DKTHTCPPCP APELLGGPSV FLFPPKPKDT LMISRTPEVT CVVVDVSHED PEVKFNWYVD GVEVHNAKTK PREEQYNSTY RVVSVLTVLH QDWLNGKEYK CKVSNKALPA PIEKTISKAK GQPREPQVYT LPPSREEMTK NQVSLTCLVK GFYPSDIAVE WESNGQPENN YKTTPPVLDS DGSFFLYSKL TVDKSRWQQG NVFSCSVMHE ALHNHYTQKS LSLSPGK

Characteristics: Recombinant Human Neuronal cell adhesion molecule/NRCAM is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (Gln25-Asn600) of Human NRCAM fused with a FC tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4 .

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: 4 °C/-20 °C/-80 °C

Storage Comment: Lyophilized protein should be stored at < -20°C, though stable at room temperature for 3 weeks.
Reconstituted protein solution can be stored at 4-7°C for 2-7 days.
Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Expiry Date: 3 months

Target Details

Target: NrCAM (NRCAM) (Neuronal Cell Adhesion Molecule (NRCAM))

Alternative Name: Neuronal Cell Adhesion Molecule/NRCAM (NRCAM Products)

Synonyms: CD56 Protein, MSK39 Protein, NCAM Protein, Bravo Protein, C030017F07Rik Protein, C130076O07Rik Protein, mKIAA0343 Protein, NRCAM Protein, si:dkey-240a12.1 Protein, Nr-CAM Protein, neural cell adhesion molecule 1 Protein, neuronal cell adhesion molecule Protein, neuronal cell adhesion molecule L homeolog Protein, neuronal cell adhesion molecule a Protein, NCAM1 Protein, NRCAM Protein, Nrcam Protein, nrcam.L Protein, nrcama Protein, nrcam Protein

Sub Type: Fusionprotein

Background: Neuronal cell adhesion molecule(NRCAM) is a single-pass type I membrane protein ,containing 5 fibronectin type-III domains and 6 Ig-like C2-type (immunoglobulin-like) domains.It belongs to the immunoglobulin superfamily. NrCAM is engaged in such biological processes as axonal fasciculation, cell-cell adhesion, central nervous system development, clustering of voltage-gated sodium channels, neuron migration, positive regulation of neuron differentiation, regulation of axon extension, and synaptogenesis. It also may play a role in the molecular assembly of the nodes of Ranvier. NrCAM effects are also linked with different recognition processes and signal transduction pathways regulating cell differentiation, proliferation, or migration
Alternative Names: Neuronal cell adhesion molecule, Nr-CAM, Neuronal surface protein Bravo, hBravo, gCAM-related cell adhesion molecule, Ng-CAM-related, KIAA0343

Molecular Weight: 91.2 kDa

Pathways: Regulation of Cell Size