GALNT3 Protein (AA 38-633) (His tag)

Catalog No. ABIN1945460

Product Details

Target: GALNT3 (UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 3 (GalNAc-T3) (GALNT3))

Protein Type: Recombinant

Protein Characteristics: AA 38-633

Origin: Human

Source: Human Cells

Purification tag / Conjugate: This GALNT3 protein is labelled with His tag.

Purpose: Recombinant Human Polypeptide GalNac Transferase 3/GALNT3 (C-6His)

Sequence: QREVSVQYSK EESRMERNMK NKNKMLDLML EAVNNIKDAM PKMQIGAPVR QNIDAGERPC LQGYYTAAEL KPVLDRPPQD SNAPGASGKA FKTTNLSVEE QKEKERGEAK HCFNAFASDR ISLHRDLGPD TRPPECIEQK FKRCPPLPTT SVIIVFHNEA WSTLLRTVHS VLYSSPAILL KEIILVDDAS VDEYLHDKLD EYVKQFSIVK IVRQRERKGL ITARLLGATV ATAETLTFLD AHCECFYGWL EPLLARIAEN YTAVVSPDIA SIDLNTFEFN KPSPYGSNHN RGNFDWSLSF GWESLPDHEK QRRKDETYPI KTPTFAGGLF SISKEYFEYI GSYDEEMEIW GGENIEMSFR VWQCGGQLEI MPCSVVGHVF RSKSPHSFPK GTQVIARNQV RLAEVWMDEY KEIFYRRNTD AAKIVKQKAF GDLSKRFEIK HRLQCKNFTW YLNNIYPEVY VPDLNPVISG YIKSVGQPLC LDVGENNQGG KPLIMYTCHG LGGNQYFEYS AQHEIRHNIQ KELCLHAAQG LVQLKACTYK GHKTVVTGEQ IWEIQKDQLL YNPFLKMCLS ANGEHPSLVS CNPSDPLQKW ILSQNDVDHH HHHH

Characteristics: Recombinant Human GALNT3 is produced by our mammalian expression system in human cells. The target protein is expressed with sequence (AA 39-633) of Human GALNT3 fused with a polyhistidine tag at the C-terminus.

Purity: > 95 % as determined by reducing SDS-PAGE.

Sterility: 0.2 μm filtered

Endotoxin Level: Less than 0.1 ng/μg (1 IEU/μg) as determined by LAL test

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Reconstitution: It is not recommended to reconstitute to a concentration less than 100 μg/mL.
Dissolve the lyophilized protein in ddH2O.
Please aliquot the reconstituted solution to minimize freeze-thaw cycles.

Buffer: Supplied as a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Handling Advice: Always centrifuge tubes before opening. Do not mix by vortex or pipetting.

Storage: -80 °C

Storage Comment: Store at < -20°C, stable for 6 months after receipt.
Please minimize freeze-thaw cycles.

Expiry Date: 6 months

Target Details

Target: GALNT3 (UDP-N-Acetyl-alpha-D-Galactosamine:polypeptide N-Acetylgalactosaminyltransferase 3 (GalNAc-T3) (GALNT3))

Alternative Name: GALNT3 (GALNT3 Products)

Synonyms: GalNAc-T3 Protein, HFTC Protein, HHS Protein, polypeptide N-acetylgalactosaminyltransferase 3 Protein, Galnt3 Protein, GALNT3 Protein

Background: Polypeptide N-acetylgalactosaminyltransferase 3(GALNT3) belongs to the glycosyltransferase 2 family and galNAc-T subfamily. It expressed in organs that contain secretory epithelial glands and it highly expressed in pancreas, skin, kidney and testis. There are two conserved domains in the glycosyltransferase region: the N-terminal domain (domain A, also called GT1 motif), which is probably involved in manganese coordination and substrate binding and the C-terminal domain (domain B, also called Gal/GalNAc-T motif), which is probably involved in catalytic reaction and UDP-Gal binding .This protein plays a major role in regulating phosphate levels within the body (phosphate homeostasis). Among its many functions, phosphate plays a critical role in the formation and growth of bones in childhood and helps maintain bone strength in adults.

Molecular Weight: 69.1 kDa

UniProt: Q14435