GDF10 Protein (AA 369-478)
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- Target See all GDF10 Proteins
- GDF10 (Growth Differentiation Factor 10 (GDF10))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 369-478
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Characteristics
- AA 369-478, expressed with an N-terminal Met.
- Purity
- > 95 % as analyzed by SDS-PAGE and HPLC.
- Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product GDF10 Protein
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Growth Differentiation Factor 10 (GDF10) (AA 379-478) protein (GST tag)
GDF10 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Growth Differentiation Factor 10 (GDF10) (AA 1-288) protein (GST tag)GDF10 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Growth Differentiation Factor 10 (GDF10) (AA 369-478) protein (His tag)Crystallography grade GDF10 Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Growth Differentiation Factor 10 (GDF10) (AA 367-476) protein (His tag)Crystallography grade GDF10 Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
Growth Differentiation Factor 10 (GDF10) proteinGDF10 Origin: Mouse Host: Escherichia coli (E. coli) Recombinant > 95 % SDS, WB, ELISA, IP
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in 4 mM HCl at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against 4 mM HCl.
- Storage
- -80 °C
- Storage Comment
- Lyophilized recombinant human Bone Morphogenetic Protein-3B (rhBMP-3B) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhBMP-3B remains stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
- Expiry Date
- 6 months
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- Target
- GDF10 (Growth Differentiation Factor 10 (GDF10))
- Alternative Name
- Bone Morphogenetic Protein-3B (BMP-3B) (GDF10 Products)
- Synonyms
- GDF10 Protein, BMP-3b Protein, BMP3B Protein, Bmp3b Protein, bmp3b Protein, gdf-10 Protein, xBMP-3b Protein, growth differentiation factor 10 Protein, growth differentiation factor 10 L homeolog Protein, GDF10 Protein, Gdf10 Protein, gdf10.L Protein
- Background
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Bone Morphogenetic Protein-3B (BMP-3B) , also known as Growth/Differentiation Factor 10 (GDF-10), is a cytokine belonging to the Transforming Growth Factor beta (TGF-beta) superfamily. BMP-3B contains the cystine knot motif shared by other TGF-beta family members. BMP-3B was originally identified by PCR based on the BMP-3 sequence, and shares 83 % identity with BMP-3. BMP-3B and BMP-2 act as mutual antagonists, as they compete for the availability of signaling protein Smad4. In vivo, BMP-3B is highly expressed in brain, lungs, and bone tissues. The functions of BMP-3B include acting as a dorsaling factor in head development, inhibition of adipogenesis in adipocytes, and induction of bone formation. BMP-3B is down-regulated in lung cancer patient samples, indicating its potential antitumor activity. Recombinant human Bone Morphogenetic Protein-3B (rhBMP-3B) produced in E. coli is a disulfide-linked homodimer containing two non-glycosylated polypeptide chains of 111 amino acids each. rhBMP-3B has a molecular mass of 25.1 kDa analyzed by non-reducing SDS-PAGE.
Synonyms: Osteogenin, BMP-3A - Molecular Weight
- 25.1 kDa, observed by non-reducing SDS-PAGE.
- UniProt
- P55107
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