IL-6 Protein (AA 25-211) (His tag)
Quick Overview for IL-6 Protein (AA 25-211) (His tag) (ABIN2018146)
Target
See all IL-6 (IL6) ProteinsProtein Type
Biological Activity
Origin
Source
Purity
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Protein Characteristics
- AA 25-211
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Purification tag / Conjugate
- This IL-6 protein is labelled with His tag.
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Characteristics
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ED50 < 3 pg /mL, measured in a bioassay using 7TD1 cells.
AA 25-211, expressed with C-terminal 6xHis. -
Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
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Interleukin 6 (IL6) (AA 30-212) protein (mFc-His Tag)
IL6 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA, FACS
Interleukin 6 (IL6) (AA 30-212) proteinIL6 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC
Interleukin 6 (IL6) (AA 28-212) protein (His tag)IL6 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 6 (IL6) (AA 29-212) (Active) proteinIL6 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE analysis. Active
Interleukin 6 (IL6) (AA 30-212) (Active) proteinIL6 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 6 (IL6) (AA 30-212) (Active) protein (His tag)IL6 Origin: Human Host: HEK-293 Cells > 97 % AcA, CC Active
Interleukin 6 (IL6) (AA 25-211) protein (Fc Tag)IL6 Origin: Mouse Host: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 6 (IL6) (AA 47-241) protein (His tag)IL6 Origin: Chicken Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
Interleukin 6 (IL6) (AA 21-207) protein (His tag)IL6 Origin: Dog Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
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Buffer
- Lyophilized after extensive dialysis against PBS.
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Storage
- -80 °C
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Storage Comment
- Lyophilized recombinant murine Interleukin-6 (IL-6), His, Murine remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, murine Interleukin-6 (IL-6), His should be stable up to 1 week at 4 °C or up to 2 months at -20 °C.
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Expiry Date
- 6 months
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- IL-6 (IL6) (Interleukin 6 (IL6))
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Alternative Name
- Interleukin-6 (IL-6)
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Background
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Interleukin-6 (IL-6), also known as BSF-2, CDF and IFNB2, is a pleiotropic cytokine that participates in both pro-inflammatory and anti-inflammatory responses. It is produced mainly by T cells, macrophages, monocytes, endothelial cells and muscle cells. IL-6 binds to IL-6 receptor (IL-6R) to trigger the association of IL-6R with gp130, inducing signal transduction through JAKs and STATs. The biological functions of IL-6 are diverse. It stimulates B cell differentiation and antibody production, myeloma and plasmacytoma growth, and nerve cell differentiation. It also acts as a myokine, produced by muscle cells in response to muscle contraction and released into the blood stream to help break down fats and improve insulin resistance.
Synonyms: 26 kDa protein, IFN-b2, B cell differentiation factor (BCDF), BSF-2, HPGF, HSF, MGI-2 -
Molecular Weight
- 24-26 kDa, observed by reducing SDS-PAGE.
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UniProt
- P08505
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Pathways
- TLR Signaling, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagy, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome
Target
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