Oncostatin M Protein (OSM) (AA 26-234)
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- Target See all Oncostatin M (OSM) Proteins
- Oncostatin M (OSM)
- Protein Type
- Recombinant
- Biological Activity
- Active
- Protein Characteristics
- AA 26-234
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Characteristics
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ED50 < 10 ng/mL, measured by a cell proliferation assay using TF-1 cells, corresponding to a specific activity of > 1x 10^5 units/mg.
AA 26-234, expressed with an N-terminal Met. - Purity
- > 95 % as analyzed by SDS-PAGE and HPLC.
- Endotoxin Level
- < 0.2 EU/μg, determined by LAL method.
- Top Product
- Discover our top product OSM Protein
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Oncostatin M (OSM) (AA 26-221) protein (His-Avi Tag)
OSM Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Oncostatin M (OSM) (Active) proteinOSM Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS-PAGE Func Active
Oncostatin M (OSM) (AA 25-206) protein (His tag)OSM Origin: Mouse Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Oncostatin M (OSM) protein (His-Avi Tag,Biotin)OSM Origin: Human Host: HEK-293 Cells Recombinant > 95% as determined by Tris-Bis PAGE,> 95% as determined by HPLC
Oncostatin M (OSM) (AA 26-239) protein (His tag)OSM Origin: Rat Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Oncostatin M (OSM) (AA 26-221) protein (His tag)OSM Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % by SDS-PAGE gel analyses WB, ELISA
Oncostatin M (OSM) (AA 26-234) protein (His tag)OSM Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % by SDS - PAGE SDS
Oncostatin M (OSM) (AA 1-252) protein (GST tag)OSM Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Oncostatin M (OSM) (AA 25-206) protein (His tag)Crystallography grade OSM Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA, Crys
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstituted in ddH2O or PBS at 100 μg/mL.
- Buffer
- Lyophilized after extensive dialysis against PBS.
- Storage
- -80 °C
- Storage Comment
- Lyophilized recombinant human Oncostatin M(209 a.a.) (rhOSM) remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, rhOSM should be stable up to 2 weeks at 4 °C or up to 3 months at -20 °C.
- Expiry Date
- 6 months
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- Target
- Oncostatin M (OSM)
- Abstract
- OSM Products
- Synonyms
- OSM Protein, OncoM Protein, oncostatin M Protein, OSM Protein, Osm Protein
- Background
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Oncostatin M (OSM) is a multifunctional cytokine, and belongs to Interleukin-6 (IL-6) subfamily, which also includes IL-11, leukemia inhibitory factor (LIF), ciliary neurotropic factor, cardiotrophin-1, and novel neurotropin-1. In vivo, OSM is secreted from activated T cells, monocytes, neutrophils, and endothelial cells. OSM is related to LIF, and shares a receptor with LIF in human. Human OSM can bind to gp130 and recruit OSM Receptor beta or LIF Receptor beta to form a ternary complex. OSM stimulates the growth of different types of cells, including megakaryocytes, fibroblasts, vascular endothelial cells, and T cells. OSM inhibits the proliferation of several cancer cell lines, such as solid tissue tumor cells, lung cancer cells, melanoma cells, and breast cancer cells. Recombinant human Oncostatin M(209 a.a.) (rhOSM) produced in E. coli is a single non-glycosylated polypeptide chain containing 210 amino acids. A fully biologically active molecule, rhOSM has a molecular mass of 23.8 kDa analyzed by reducing SDS-PAGE.
Synonyms: OSM - Molecular Weight
- 23.8 kDa, observed by reducing SDS-PAGE.
- UniProt
- P13725
- Pathways
- JAK-STAT Signaling, Negative Regulation of Hormone Secretion
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