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beta-Thromboglobulin Protein (beta-TG) (AA 46-107)

beta-TG Origin: Rat Host: CHO Cells Recombinant > 97 % as analyzed by SDS-PAGE and HPLC. Active
Catalog No. ABIN2018401
  • Target See all beta-Thromboglobulin (beta-TG) Proteins
    beta-Thromboglobulin (beta-TG)
    Protein Type
    Recombinant
    Biological Activity
    Active
    Protein Characteristics
    AA 46-107
    Origin
    • 2
    • 1
    • 1
    • 1
    Rat
    Source
    • 5
    CHO Cells
    Characteristics
    The EC50 value of rat Thymus Chemokine-1/CXCL7 on Ca2+ mobilization assay in CHO-K1/G alpha 15/rCXCR2 cells (human G alpha 15 and rat CXCR2 stably expressed in CHO-K1 cells) is less than 300 ng/mL.
    Purity
    > 97 % as analyzed by SDS-PAGE and HPLC.
    Endotoxin Level
    < 0.2 EU/μg, determined by LAL method.
  • Restrictions
    For Research Use only
  • Format
    Lyophilized
    Reconstitution
    Reconstituted in ddH2O or PBS at 100 μg/mL.
    Buffer
    Lyophilized after extensive dialysis against PBS.
    Storage
    -80 °C
    Storage Comment
    Lyophilized recombinant Rat Thymus Chemokine-1/CXCL7 remains stable up to 6 months at -80 °C from date of receipt. Upon reconstitution, Rat Thymus Chemokine-1/CXCL7 should be stable up to 1 week at 4 °C or up to 3 months at -20 °C.
    Expiry Date
    6 months
  • Target
    beta-Thromboglobulin (beta-TG)
    Abstract
    beta-TG Products
    Synonyms
    B-TG1 Protein, Beta-TG Protein, CTAP-III Protein, CTAP3 Protein, CTAPIII Protein, CXCL7 Protein, LA-PF4 Protein, LDGF Protein, MDGF Protein, NAP-2 Protein, PBP Protein, SCYB7 Protein, TC1 Protein, TC2 Protein, TGB Protein, TGB1 Protein, THBGB Protein, THBGB1 Protein, CTAPIII/NAP-2 Protein, 2400003M24Rik Protein, AI854500 Protein, Cxcl7 Protein, NAP-2-L1 Protein, Scyb7 Protein, b-TG1 Protein, beta-TG Protein, Nap-2 Protein, pro-platelet basic protein Protein, PPBP Protein, Ppbp Protein
    Background
    Thymus Chemokine-1, also called Chemokine (C-X-C motif) ligand 7 (CXCL7) , is a member of the CXC chemokines. Similar to other ELR domain containing CXC chemokines such as IL-8 and the GRO proteins, Thymus Chemokine-1 has been shown to bind CXCR-2 and be a chemoattractant forneutrophils and play a role in their activation. Although CTAP-III, beta-TG and PBP represent amino-terminal extended variants of Thymus Chemokine-1 and possess the same CXC chemokine domains, these proteins do not exhibit Thymus Chemokine-1 activity. Recently, it has been shown that the additional amino-terminal residues of CTAP-III mask the critical ELR receptor binding domain that is exposed on Thymus Chemokine-1 and may account for lack of Thymus Chemokine-1 activity. Rat CXCL7 shares 72 % amino acid sequence identity with mouse CXCL7.Recombinant rat Thymus Chemokine-1/ CXCL7 produced in CHO cells is a polypeptide chain containing 62 amino acids. A fully biologically active molecule, rrThymus Chemokine-1/CXCL7 has a molecular mass of 9.8 kDa analyzed by reducing SDS-PAGE.
    Synonyms: Thymus Chemokine-1,TCK-1
    Molecular Weight
    9.8 kDa, observed by reducing SDS-PAGE.
    UniProt
    Q99ME0
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