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Pertussis Toxin (ARTC) (Active) Protein Protein

ARTC Origin: Bordetella pertussis Host: Bordetella pertussis Native Func Active
Pubmed (1)
Catalog No. ABIN2452202
$596.92
Plus shipping costs $45.00
25 μg
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  • Target
    Pertussis Toxin (ARTC)
    Protein Type
    Native
    Biological Activity
    Active
    Origin
    Bordetella pertussis
    Source
    Bordetella pertussis
    Application
    Functional Studies (Func)
    Characteristics
    This product was highly purified (>90 % pure) from Bordetella pertussis strain Tohama by the method of Skelton & Wong. Cytotoxicity of the PT was confirmed by morphological alteration of CHO cells after treatment with 0.1 ng/mL of PT.
  • Application Notes
    1. Studies on the signal transduction of the trimeric GTP binding proteins.
    2. Therapeutic role in treating a number of diseases including hypertention,viral and autoimumune inhibitions.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Concentration
    83 µg/mL
    Buffer
    10 % glycerol, 10 mM phoshate buffer ( pH 7. 4), 137 mM NaCl
    Storage
    -80 °C
  • Skelton, Wong: "Simple, efficient purification of filamentous hemagglutinin and pertussis toxin from Bordetella pertussis by hydrophobic and affinity interaction." in: Journal of clinical microbiology, Vol. 28, Issue 5, pp. 1062-5, 1990 (PubMed).

  • Target
    Pertussis Toxin (ARTC)
    Background
    Perrtussis toxin (PT) is a protein-based AB5-type exotoxin produced by Bordeterra pertussis. PT catalyzes the ADP-ribosylation of the alpha subunits of the heterotrimeric guanine nucleotide regulatory proteins Gi, Go, and Gt and prevents intracellular signal transduction involving the G proteins. PT consists of one moplecule of each S1 (26 kDa), S2 (22 kDa), S3 (22 kDa), S5 (12 kDa) and two molecule of S4 (12 kDa).
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