Cyclin D1 Protein (CCND1) (Myc-DYKDDDDK Tag)
Quick Overview for Cyclin D1 Protein (CCND1) (Myc-DYKDDDDK Tag) (ABIN2712723)
Target
See all Cyclin D1 (CCND1) ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This Cyclin D1 protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human Cyclin D1 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Cyclin D1 (CCND1) (AA 1-295) protein (His tag)
custom-made CCND1 Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Cyclin D1 (CCND1) (AA 1-295) protein (His tag)custom-made CCND1 Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
Cyclin D1 (CCND1) (AA 1-295) protein (GST tag)CCND1 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- Cyclin D1 (CCND1)
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Alternative Name
- Cyclin d1
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Background
- The protein encoded by this gene belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance throughout the cell cycle. Cyclins function as regulators of CDK kinases. Different cyclins exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell cycle G1/S transition. This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated positively by Rb. Mutations, amplification and overexpression of this gene, which alters cell cycle progression, are observed frequently in a variety of tumors and may contribute to tumorigenesis.
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Molecular Weight
- 33.5 kDa
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NCBI Accession
- NP_444284
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Pathways
- PI3K-Akt Signaling, Cell Division Cycle, Mitotic G1-G1/S Phases, ER-Nucleus Signaling
Target
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