CARD11 Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2713159

Product Details

Target: CARD11 (Caspase Recruitment Domain Family, Member 11 (CARD11))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This CARD11 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human CARD11 / CARMA1 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: CARD11 (Caspase Recruitment Domain Family, Member 11 (CARD11))

Alternative Name: Card11,carma1 (CARD11 Products)

Synonyms: BENTA Protein, BIMP3 Protein, CARMA1 Protein, PPBL Protein, 0610008L17Rik Protein, 2410011D02Rik Protein, CARD11 Protein, LOC100232755 Protein, caspase recruitment domain family member 11 Protein, caspase recruitment domain family, member 11 Protein, caspase recruitment domain-containing protein 11 Protein, CARD11 Protein, Card11 Protein, LOC100550812 Protein, card11 Protein

Background: The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10.

Molecular Weight: 133.1 kDa

NCBI Accession: NP_115791

Pathways: TCR Signaling, Fc-epsilon Receptor Signaling Pathway, BCR Signaling