BAX Protein (Myc-DYKDDDDK Tag)
Quick Overview for BAX Protein (Myc-DYKDDDDK Tag) (ABIN2715165)
Target
See all BAX ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This BAX protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human Bax (transcript variant alpha) protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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BCL2-Associated X Protein (BAX) (AA 1-192) protein (GST tag)
BAX Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
BCL2-Associated X Protein (BAX) (AA 1-100) protein (GST tag)BAX Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
BCL2-Associated X Protein (BAX) (AA 1-110) protein (His-IF2DI Tag)BAX Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
BCL2-Associated X Protein (BAX) (AA 1-171) protein (His-IF2DI Tag)BAX Origin: Mouse Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. WB, ELISA
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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- BAX (BCL2-Associated X Protein (BAX))
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Alternative Name
- Bax
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Background
- The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein forms a heterodimer with BCL2, and functions as an apoptotic activator. This protein is reported to interact with, and increase the opening of, the mitochondrial voltage-dependent anion channel (VDAC), which leads to the loss in membrane potential and the release of cytochrome c. The expression of this gene is regulated by the tumor suppressor P53 and has been shown to be involved in P53-mediated apoptosis. Multiple alternatively spliced transcript variants, which encode different isoforms, have been reported for this gene.
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Molecular Weight
- 21 kDa
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NCBI Accession
- NP_620116
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Pathways
- p53 Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity, Unfolded Protein Response
Target
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