LIG1 Protein (Myc-DYKDDDDK Tag)
(1 reference)Quick Overview for LIG1 Protein (Myc-DYKDDDDK Tag) (ABIN2719545)
Target
See all LIG1 ProteinsProtein Type
Origin
Source
Application
Purity
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Purification tag / Conjugate
- This LIG1 protein is labelled with Myc-DYKDDDDK Tag.
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Characteristics
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- Recombinant human DNA ligase 1 protein expressed in HEK293 cells.
- Produced with end-sequenced ORF clone
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Ligase I, DNA, ATP-Dependent (LIG1) (AA 810-919) protein (GST tag)
LIG1 Origin: Human Host: Wheat germ Recombinant AP, AA, ELISA, WB
Ligase I, DNA, ATP-Dependent (LIG1) (AA 1-919), (full length) protein (GST tag)LIG1 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 90 % as determined by SDS-PAGE. SDS
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Application Notes
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Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays -
Comment
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The tag is located at the C-terminal.
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Restrictions
- For Research Use only
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Concentration
- 50 μg/mL
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Buffer
- 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
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Storage
- -80 °C
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Storage Comment
- Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
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: "Okazaki fragment maturation involves α-segment error editing by the mammalian FEN1/MutSα functional complex." in: The EMBO journal, Vol. 34, Issue 13, pp. 1829-43, (2015) (PubMed).
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- LIG1 (Ligase I, DNA, ATP-Dependent (LIG1))
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Alternative Name
- Dna Ligase 1
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Background
- This gene encodes a member of the ATP-dependent DNA ligase protein family. The encoded protein functions in DNA replication, recombination, and the base excision repair process. Mutations in this gene that lead to DNA ligase I deficiency result in immunodeficiency and increased sensitivity to DNA-damaging agents. Disruption of this gene may also be associated with a variety of cancers. Alternative splicing results in multiple transcript variants.
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Molecular Weight
- 101.6 kDa
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NCBI Accession
- NP_000225
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Pathways
- Telomere Maintenance, DNA Damage Repair, DNA Replication, Synthesis of DNA
Target
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