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Fibulin 5 Protein (FBLN5) (Myc-DYKDDDDK Tag)

FBLN5 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
Catalog No. ABIN2721183
  • Target See all Fibulin 5 (FBLN5) Proteins
    Fibulin 5 (FBLN5)
    Protein Type
    Recombinant
    Origin
    • 4
    • 3
    • 3
    • 1
    Human
    Source
    • 6
    • 2
    • 2
    • 1
    HEK-293 Cells
    Purification tag / Conjugate
    This Fibulin 5 protein is labelled with Myc-DYKDDDDK Tag.
    Application
    Antibody Production (AbP), Standard (STD)
    Characteristics
    • Recombinant human Fibulin-5 protein expressed in HEK293 cells.
    • Produced with end-sequenced ORF clone
    Purity
    > 80 % as determined by SDS-PAGE and Coomassie blue staining
    Top Product
    Discover our top product FBLN5 Protein
  • Application Notes
    Recombinant human proteins can be used for:
    Native antigens for optimized antibody production
    Positive controls in ELISA and other antibody assays
    Comment

    The tag is located at the C-terminal.

    Restrictions
    For Research Use only
  • Concentration
    50 μg/mL
    Buffer
    25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.
    Storage
    -80 °C
    Storage Comment
    Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.
  • Sideek, Menz, Parsi, Gibson: "LTBP-2 competes with tropoelastin for binding to fibulin-5 and heparin, and is a negative modulator of elastinogenesis." in: Matrix biology : journal of the International Society for Matrix Biology, Vol. 34, pp. 114-23, (2014) (PubMed).

  • Target
    Fibulin 5 (FBLN5)
    Alternative Name
    Fibulin-5 (FBLN5 Products)
    Synonyms
    zgc:103575 Protein, FBLN5 Protein, MGC108414 Protein, Fibulin-5 Protein, DKFZp469K0327 Protein, ADCL2 Protein, ARCL1A Protein, ARMD3 Protein, DANCE Protein, EVEC Protein, FIBL-5 Protein, UP50 Protein, A55 Protein, fibulin 5 Protein, fbln5 Protein, FBLN5 Protein, Fbln5 Protein
    Background
    The protein encoded by this gene is a secreted, extracellular matrix protein containing an Arg-Gly-Asp (RGD) motif and calcium-binding EGF-like domains. It promotes adhesion of endothelial cells through interaction of integrins and the RGD motif. It is prominently expressed in developing arteries but less so in adult vessels. However, its expression is reinduced in balloon-injured vessels and atherosclerotic lesions, notably in intimal vascular smooth muscle cells and endothelial cells. Therefore, the protein encoded by this gene may play a role in vascular development and remodeling. Defects in this gene are a cause of autosomal dominant cutis laxa, autosomal recessive cutis laxa type I (CL type I), and age-related macular degeneration type 3 (ARMD3).
    Molecular Weight
    47.8 kDa
    NCBI Accession
    NP_006320
    Pathways
    SARS-CoV-2 Protein Interactome
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