SH2D1A Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag)

Catalog No. ABIN2731954

This Recombinant SH2D1A protein is expressed in HEK-293 Cells.

Quick Overview for SH2D1A Protein (Transcript Variant 1) (Myc-DYKDDDDK Tag) (ABIN2731954)

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Application: Antibody Production (AbP), Standard (STD)

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Product Details

Protein Characteristics: Transcript Variant 1

Purification tag / Conjugate: This SH2D1A protein is labelled with Myc-DYKDDDDK Tag.

Characteristics:

• Recombinant human SH2D1A (transcript variant 1) protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: SH2D1A (SH2 Domain Containing 1A (SH2D1A))

Alternative Name: Sh2d1a

Background: This gene encodes a protein that plays a major role in the bidirectional stimulation of T and B cells. This protein contains an SH2 domain and a short tail. It associates with the signaling lymphocyte-activation molecule, thereby acting as an inhibitor of this transmembrane protein by blocking the recruitment of the SH2-domain-containing signal-transduction molecule SHP-2 to its docking site. This protein can also bind to other related surface molecules that are expressed on activated T, B and NK cells, thereby modifying signal transduction pathways in these cells. Mutations in this gene cause lymphoproliferative syndrome X-linked type 1 or Duncan disease, a rare immunodeficiency characterized by extreme susceptibility to infection with Epstein-Barr virus, with symptoms including severe mononucleosis and malignant lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene.

Molecular Weight: 14 kDa

NCBI Accession: NP_002342

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process