TRIM68 Protein (Myc-DYKDDDDK Tag)

Catalog No. ABIN2734291

Product Details

Target: TRIM68 (Tripartite Motif Containing 68 (TRIM68))

Protein Type: Recombinant

Origin: Human

Source: HEK-293 Cells

Purification tag / Conjugate: This TRIM68 protein is labelled with Myc-DYKDDDDK Tag.

Application: Antibody Production (AbP), Standard (STD)

Characteristics:

• Recombinant human TRIM68 / RNF137 protein expressed in HEK293 cells.
• Produced with end-sequenced ORF clone

Purity: > 80 % as determined by SDS-PAGE and Coomassie blue staining

Application Details

Application Notes: Recombinant human proteins can be used for:
Native antigens for optimized antibody production
Positive controls in ELISA and other antibody assays

Comment:

The tag is located at the C-terminal.

Restrictions: For Research Use only

Handling

Concentration: 50 μg/mL

Buffer: 25 mM Tris.HCl, pH 7.3, 100 mM glycine, 10 % glycerol.

Storage: -80 °C

Storage Comment: Store at -80°C. Thaw on ice, aliquot to individual single-use tubes, and then re-freeze immediately. Only 2-3 freeze thaw cycles are recommended.

Target Details

Target: TRIM68 (Tripartite Motif Containing 68 (TRIM68))

Alternative Name: Trim68,rnf137 (TRIM68 Products)

Synonyms: GC109 Protein, RNF137 Protein, SS-56 Protein, SS56 Protein, AI894158 Protein, F730114J12Rik Protein, Rnf137 Protein, TRIM68 Protein, tripartite motif containing 68 Protein, tripartite motif-containing 68 Protein, E3 ubiquitin-protein ligase TRIM68 Protein, TRIM68 Protein, Trim68 Protein, LOC100053519 Protein

Background: This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a 'really interesting new gene' (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as E3 ubiquitin ligases and are involved in a broad range of biological processes. This gene regulates the activation of nuclear receptors, such as androgen receptor, and has been implicated in development of prostate cancer cells, where its expression increases in response to a downregulation of microRNAs. In addition, this gene participates in viral defense regulation as a negative regulator of interferon-beta. Alternative splicing results in multiple transcript variants.

Molecular Weight: 56.1 kDa

NCBI Accession: NP_060543

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling