C19ORF80 Protein (Fc Tag)
C19ORF80
Origin: Human
Host: HEK-293 Cells
Recombinant
>90 % (SDS-PAGE)
SDS
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- Target See all C19ORF80 Proteins
- C19ORF80 (Chromosome 19 Open Reading Frame 80 (C19ORF80))
- Protein Type
- Recombinant
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Origin
- Human
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This C19ORF80 protein is labelled with Fc Tag.
- Application
- SDS-PAGE (SDS)
- Cross-Reactivity
- Human
- Characteristics
- Human betatrophin (22-198) is fused at the C-terminus to the Fc portion of human IgG1.
- Purity
- >90 % (SDS-PAGE)
- Endotoxin Level
- <0.1EU/μg purified protein (LAL test, Lonza).
- Top Product
- Discover our top product C19ORF80 Protein
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Chromosome 19 Open Reading Frame 80 (C19ORF80) (AA 22-198) protein (His tag)
C19ORF80 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Chromosome 19 Open Reading Frame 80 (C19ORF80) protein (GST tag)C19ORF80 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Reconstitute with 100 μL sterile water.
- Concentration
- Lot specific
- Buffer
- Lyophilized. Contains PBS + 0.02 % CHAPS.
- Storage
- 4 °C,-20 °C
- Storage Comment
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Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 6 months after receipt when stored at -20°C. - Expiry Date
- 6 months
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- Target
- C19ORF80 (Chromosome 19 Open Reading Frame 80 (C19ORF80))
- Alternative Name
- Betatrophin (C19ORF80 Products)
- Synonyms
- ANGPTL8 Protein, PRO1185 Protein, PVPA599 Protein, RIFL Protein, TD26 Protein, angiopoietin like 8 Protein, ANGPTL8 Protein
- Background
- Betatrophin (RIFL, Lipasin, Angiopoietin-like protein 8 (ANGPTL8)) is a newly discovered secreted protein of 198 aa that was proposed to promote beta cell proliferation and improve glucose tolerance in mice. Betatrophin may also function in inhibition of lipase activity and on serum triglyceride regulation. Betatrophin is expressed in the liver and in white and brown adipose tissue of mice. In humans, betatrophin is found to be predominantly expressed in the liver. Betatrophin levels are reduced by fasting and are elevated upon insulin resistance and during pregnancy. Betatrophin, according to preliminary data could bind to the macrophage receptor Marco and also to RTN4R, a neuronal receptor. Recently, a study using ANGPTL8 KO mice showed that ANGPTL8/Betatrophin does not play a role in beta cell proliferation nor in glycemic control as previously thought, but regulates plasma triglyceride levels.
- Molecular Weight
- ~50kDa
- UniProt
- Q6UXH0
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