IL-6 Protein
Quick Overview for IL-6 Protein (ABIN2830814)
Target
See all IL-6 (IL6) ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
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Sequence
- MAPVLPGEDS KNVAAPHSQP LTSSERIDKH IRYILDGISA LRKETCNRSN MCESSKEALA ENNLNLPKMA EKDGCFQSGF NEDTCLVKII TGLLEFEVYL EYLQNRFESS EEQARAVQMS TKVLIQFLQK KAKNLDAITT PEPTTNASLL TKLQAQNQWL QDMTTHLILR SFKEFLQSNL RALRQM
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Characteristics
- Biological Activity: Fully biologically active when compared to standard. The ED50 as determined by a cell proliferation assay usingIL-6-dependent murine 7TD1 cells is less than 0.1 ng/mL, corresponding to a specific activity of ＞ 1.0 x 107 IU/mg.
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Sterility
- 0.2 μm filtered
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Interleukin 6 (IL6) (AA 30-212) protein (mFc-His Tag)
IL6 Origin: Human Host: HEK-293 Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining. ELISA, FACS
Interleukin 6 (IL6) (AA 30-212) proteinIL6 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % as determined by Tris-Bis PAGE,> 90 % as determined by HPLC
Interleukin 6 (IL6) (AA 28-212) protein (His tag)IL6 Origin: Cynomolgus Host: HEK-293 Cells Recombinant > 95 % as determined by Tris-Bis PAGE,> 95 % as determined by HPLC
Interleukin 6 (IL6) (AA 29-212) (Active) proteinIL6 Origin: Human Host: Escherichia coli (E. coli) Recombinant > 95 % by SDS-PAGE analysis. Active
Interleukin 6 (IL6) (AA 25-211) (Active) protein (His tag)IL6 Origin: Mouse Host: CHO Cells Recombinant > 95 % as analyzed by SDS-PAGE. Active
Interleukin 6 (IL6) (AA 30-212) (Active) proteinIL6 Origin: Human Host: HEK-293 Cells Recombinant >90 % as determined by SDS-PAGE. Active
Interleukin 6 (IL6) (AA 30-212) (Active) protein (His tag)IL6 Origin: Human Host: HEK-293 Cells > 97 % AcA, CC Active
Interleukin 6 (IL6) (AA 25-211) protein (Fc Tag)IL6 Origin: Mouse Host: Mammalian Cells Recombinant The purity of the protein is greater than 95 % as determined by SDS-PAGE and Coomassie blue staining.
Interleukin 6 (IL6) (AA 25-211) protein (His tag)IL6 Origin: Rat Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Storage
- -20 °C
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- IL-6 (IL6) (Interleukin 6 (IL6))
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Alternative Name
- IL6
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Background
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Relevance: Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation (By similarity). {ECO:0000250}.
Synonyms: IL-6, -
Molecular Weight
- 21.1 kDa
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UniProt
- P51494
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Pathways
- TLR Signaling, Hormone Transport, Negative Regulation of Hormone Secretion, Myometrial Relaxation and Contraction, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Regulation of Carbohydrate Metabolic Process, Autophagy, Cell RedoxHomeostasis, Cancer Immune Checkpoints, Inflammasome
Target
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