MLL2-SET (AA 5355-5537) protein (GST tag)

Details for Product No. ABIN4889648, Supplier: Log in to see
Protein Name
Protein Characteristics
AA 5355-5537
Origin
Human
Source
Escherichia coli (E. coli)
Protein Type
Recombinant
Purification tag / Conjugate
GST tag
Application
Enzyme Activity Assay (EAA), Screening Assay (ScA)
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Characteristics The peptide corresponding to amino acids 5355 - 5537 of the MLL2 protein (accession number NP_003473.3) was expressed in E. coli. The peptide contains the SET domain of MLL2 that is responsible for methyltransferase activity. Recombinant MLL2-SET contains an N-terminal GST tag with a molecular weight of 47.6 kDa.
Protein Name
Background Myeloid/lymphoid or mixed-lineage leukemia 2 (MLL2) is a Trithorax-group protein that function collectively to promote gene expression. MLL2 is a histone methyltransferase that methylates the Lysine 4 position of histone H3. In particular, the SET domain is a conserved C-terminal domain that characterizes proteins of the MLL (mixed-lineage leukemia) family. The SET domain is responsible for its histone methyltransferase activity which mediates chromatin modifications associated with epigenetic transcriptional activation. H3K4 methylation represents a specific epigenetic tag for transcriptional activation. MLL2 is part of a large protein complex called ASCOM, which has been shown to be a transcriptional regulator of the β-globin and estrogen receptor genes. Mutations in this gene have been shown to be a cause of Kabuki syndrome.
Molecular Weight 47.6 kDa
Application Notes Recombinant MLL2-SET is suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling.
Restrictions For Research Use only
Handling Advice Avoid repeated freeze/thaw cycles and keep on ice when not in storage.
Storage -80 °C
Storage Comment Recombinant proteins in solution are temperature sensitive and must be stored at -80°C to prevent degradation.
Supplier Images
Western Blotting (WB) image for MLL2-SET (AA 5355-5537) protein (GST tag) (ABIN4889648) Recombinant MLL2-SET protein gel. MLL2-SET protein was run on a 10% SDS-PAGE gel and ...
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