nectin-3 Protein (AA 58-400) (His tag)
Quick Overview for nectin-3 Protein (AA 58-400) (His tag) (ABIN4949137)
Target
See all nectin-3 (NECTIN3) ProteinsProtein Type
Origin
Source
Application
Purity
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Protein Characteristics
- AA 58-400
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Purification tag / Conjugate
- This nectin-3 protein is labelled with His tag.
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Sequence
- AA 58-400
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Characteristics
- This protein carries a polyhistidine tag at the C-terminus. The protein has a calculated MW of 39.6 kDa. The protein migrates as 60-75 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
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Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
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Nectin cell adhesion molecule 3 (NECTIN3) (AA 58-400) (Active) protein (His-Avi Tag)
NECTIN3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Nectin cell adhesion molecule 3 (NECTIN3) (AA 58-400) (Active) protein (Biotin,His-Avi Tag)NECTIN3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Nectin cell adhesion molecule 3 (NECTIN3) (AA 58-400) (Active) protein (Fc Tag)NECTIN3 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func Active
Nectin cell adhesion molecule 3 (NECTIN3) (AA 58-400) (Active) protein (Fc Tag,AVI tag,Biotin)NECTIN3 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Nectin cell adhesion molecule 3 (NECTIN3) (AA 1-366) protein (GST tag)NECTIN3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Nectin cell adhesion molecule 3 (NECTIN3) (AA 58-404) protein (His tag)NECTIN3 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90 % SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Buffer
- PBS, pH 7.4
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Handling Advice
- Please avoid repeated freeze-thaw cycles.
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Storage
- -20 °C
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- nectin-3 (NECTIN3) (Nectin cell adhesion molecule 3 (NECTIN3))
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Alternative Name
- Nectin-3
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Background
- Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Nectins are immunoglobulin-like adhesion molecules that interact with afadin (AF6, MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells. PVRL3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Furthermore, PVRL3 induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.
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Molecular Weight
- 39.6 kDa
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UniProt
- Q9NQS3
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Pathways
- Cell-Cell Junction Organization
Target
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