nectin-3 Protein (AA 58-400) (Fc Tag)
Quick Overview for nectin-3 Protein (AA 58-400) (Fc Tag) (ABIN4949138)
Target
See all nectin-3 (NECTIN3) ProteinsProtein Type
Biological Activity
Origin
Source
Application
Purity
-
-
Protein Characteristics
- AA 58-400
-
Purification tag / Conjugate
- This nectin-3 protein is labelled with Fc Tag.
-
Sequence
- AA 58-400
-
Characteristics
- This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 64.3 kDa. The protein migrates as 80-100 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
-
Endotoxin Level
- Less than 1.0 EU per μg by the LAL method.
-
-
Want other Options for this Protein ?
!Discover Our Predefined Custom Proteins and Custom Protein Services!Your project requires further customization? Contact us and discover our custom protein solutions
-
Nectin cell adhesion molecule 3 (NECTIN3) (AA 58-400) (Active) protein (His-Avi Tag)
NECTIN3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Nectin cell adhesion molecule 3 (NECTIN3) (AA 58-400) (Active) protein (Biotin,His-Avi Tag)NECTIN3 Origin: Human Host: HEK-293 Cells Recombinant > 95 % as determined by Bis-Tris PAGE,> 95 % as determined by HPLC Active
Nectin cell adhesion molecule 3 (NECTIN3) (AA 58-400) (Active) protein (Fc Tag,AVI tag,Biotin)NECTIN3 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Active
Nectin cell adhesion molecule 3 (NECTIN3) (AA 1-366) protein (GST tag)NECTIN3 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AP, AA
Nectin cell adhesion molecule 3 (NECTIN3) (AA 58-404) protein (His tag)NECTIN3 Origin: Human Host: Baculovirus infected Insect Cells Recombinant > 90 % SDS
Nectin cell adhesion molecule 3 (NECTIN3) (AA 58-400) protein (His tag)NECTIN3 Origin: Human Host: HEK-293 Cells Recombinant >95 % as determined by SDS-PAGE. Func
-
-
Restrictions
- For Research Use only
-
-
-
Format
- Lyophilized
-
Buffer
- Tris with Glycine, Arginine and NaCl, pH 7.5
-
Handling Advice
- Please avoid repeated freeze-thaw cycles.
-
Storage
- -20 °C
-
-
- nectin-3 (NECTIN3) (Nectin cell adhesion molecule 3 (NECTIN3))
-
Alternative Name
- Nectin-3
-
Background
- Poliovirus receptor-related 3 (PVRL3), also known as nectin-3 and CD113, is a human protein of the immunoglobulin superfamily which forms part of adherens junctions. Nectins are immunoglobulin-like adhesion molecules that interact with afadin (AF6, MIM 159559). Afadin is an actin filament-binding protein that connects nectins to the actin cytoskeleton. The nectin-afadin system organizes adherens junctions cooperatively with the cadherin system in epithelial cells. PVRL3 plays a role in cell-cell adhesion through heterophilic trans-interactions with nectin-like proteins or nectins, such as trans-interaction with PVRL2/nectin-2 at Sertoli-spermatid junctions. Furthermore, PVRL3 induces endocytosis-mediated down-regulation of PVR from the cell surface, resulting in reduction of cell movement and proliferation.
-
Molecular Weight
- 64.3 kDa
-
UniProt
- Q9NQS3
-
Pathways
- Cell-Cell Junction Organization
Target
-
