KAT5 Protein (AA 3-513, partial) (His tag)

Catalog No. ABIN4984167

Product Details

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Protein Type: Recombinant

Protein Characteristics: AA 3-513, partial

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This KAT5 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: EVGEIIEGCR LPVLRRNQDN EDEWPLAEIL SVKDISGRKL FYVHYIDFNK RLDEWVTHER LDLKKIQFPK KEAKTPTKNG LPGSRPGSPE REVPASAQAS GKTLPIPVQI TLRFNLPKER EAIPGGEPDQ PLSSSSCLQP NHRSTKRKVE VVSPATPVPS ETAPASVFPQ NGAARRAVAA QPGRKRKSNC LGTDEDSQDS SDGIPSAPRM TGSLVSDRSH DDIVTRMKNI ECIELGRHRL KPWYFSPYPQ ELTTLPVLYL CEFCLKYGRS LKCLQRHLTK CDLRHPPGNE IYRKGTISFF EIDGRKNKSY SQNLCLLAKC FLDHKTLYYD TDPFLFYVMT EYDCKGFHIV GYFSKEKEST EDYNVACILT LPPYQRRGYG KLLIEFSYEL SKVEGKTGTP EKPLSDLGLL SYRSYWSQTI LEILMGLKSE SGERPQITIN EISEITSIKK EDVISTLQYL NLINYYKGQY ILTLSEDIVD GHERAMLKRL LRIDSKCLHF TPKDWSKRGK W

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: KAT5 (K(lysine) Acetyltransferase 5 (KAT5))

Alternative Name: KAT5 (KAT5 Products)

Synonyms: 6121 Protein, CG6121 Protein, DmEG0007.7 Protein, Dmel/TIP60 Protein, Dmel\\CG6121 Protein, Dmel\\TIP60 Protein, EG0007.7 Protein, EG:EG0007.7 Protein, TIP60 Protein, dTIP60 Protein, dTip60 Protein, dmHAG405 Protein, im:6908768 Protein, wu:fb55b08 Protein, zgc:110752 Protein, ESA1 Protein, HTATIP Protein, HTATIP1 Protein, PLIP Protein, TIP Protein, ZC2HC5 Protein, cPLA2 Protein, AI839539 Protein, CPLA2 Protein, Htatip Protein, Htatip1 Protein, Tip55 Protein, Tip60 Protein, K(lysine) acetyltransferase 5a Protein, lysine acetyltransferase 5 Protein, Tat interactive protein 60kDa Protein, histone acetyltransferase Tip60 Protein, tip60, putative Protein, K(lysine) acetyltransferase 5b Protein, K(lysine) acetyltransferase 5 Protein, kat5a Protein, KAT5 Protein, Tip60 Protein, LOC413101 Protein, LOC5579231 Protein, Smp_053140 Protein, kat5b Protein, Kat5 Protein

Background: Catalytic subunit of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Directly acetylates and activates ATM. Component of a SWR1-like complex that specifically mediates the roval of histone H2A.Z/H2AFZ from the nucleosome. In case of HIV-1 infection, interaction with the viral Tat protein leads to KAT5 polyubiquitination and targets it to degradation. Relieves NR1D2-mediated inhibition of APOC3 expression by acetylating NR1D2. Promotes FOXP3 acetylation and positively regulates its transcriptional repressor activity

Molecular Weight: 62.4 kDa

UniProt: Q92993

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway