SMARCC1 Protein (AA 449-669) (His tag)

Catalog No. ABIN4986572

Product Details

Target: SMARCC1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily C, Member 1 (SMARCC1))

Protein Type: Recombinant

Protein Characteristics: AA 449-669

Origin: Human

Source: Baculovirus infected Insect Cells

Purification tag / Conjugate: This SMARCC1 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: IPSYASWFDY NCIHVIERRA LPEFFNGKNK SKTPEIYLAY RNFMIDTYRL NPQEYLTSTA CRRNLTGDVC AVMRVHAFLE QWGLVNYQVD PESRPMAMGP PPTPHFNVLA DTPSGLVPLH LRSPQVPAAQ QMLNFPEKNK EKPVDLQNFG LRTDIYSKKT LAKSKGASAG REWTEQETLL LLEALEMYKD DWNKVSEHVG SRTQDECILH FLRLPIEDPY L

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: SMARCC1 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily C, Member 1 (SMARCC1))

Alternative Name: SMRC1 (SMARCC1 Products)

Synonyms: smarcc1 Protein, MGC53976 Protein, BAF155 Protein, CRACC1 Protein, Rsc8 Protein, SRG3 Protein, SWI3 Protein, AI115498 Protein, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 L homeolog Protein, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1a Protein, SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1 Protein, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 Protein, smarcc1.L Protein, smarcc1a Protein, SMARCC1 Protein, Smarcc1 Protein

Background: Involved in transcriptional activation and repression of select genes by chromatin rodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Belongs to the neural progenitors-specific chromatin rodeling complex (npBAF complex) and the neuron-specific chromatin rodeling complex (nBAF complex). During neural development a switch from a st/progenitor to a post-mitotic chromatin rodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural st/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural st cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth .

Molecular Weight: 29.5 kDa

UniProt: Q92922

Pathways: Chromatin Binding