CTHRC1 Protein (AA 31-243) (DYKDDDDK Tag)

Catalog No. ABIN5564373

This Recombinant CTHRC1 protein is produced in CHO Cells.

Quick Overview for CTHRC1 Protein (AA 31-243) (DYKDDDDK Tag) (ABIN5564373)

Target: CTHRC1 (Collagen Triple Helix Repeat Containing 1 (CTHRC1))

Protein Type: Recombinant

Origin: Human

Source: CHO Cells

Application: SDS-PAGE (SDS)

Purity: >90 % (SDS-PAGE)

Product Details

Protein Characteristics: AA 31-243

Purification tag / Conjugate: This CTHRC1 protein is labelled with DYKDDDDK Tag.

Purpose: CTHRC1 (human) (rec.)

Cross-Reactivity: Human

Characteristics: Human CTHRC1 (aa 31-243) is fused at the N-terminus to a FLAG®-tag.

Endotoxin Level: <0.01EU/μg purified protein (LAL test).

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Lyophilized

Concentration: 0.1 mg/mL

Buffer: Contains PBS.

Handling Advice: After reconstitution, prepare aliquots and store at -20 °C. Avoid freeze/thaw cycles. Centrifuge lyophilized vial before opening and reconstitution. PBS containing at least 0.1 % BSA should be used for further dilutions.

Storage: 4 °C,-20 °C

Storage Comment:

Short Term Storage: +4°C

Long Term Storage: -20°C

Use & Stability: Stable for at least 6 months after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.

Expiry Date: 6 months

Target Details

Target: CTHRC1 (Collagen Triple Helix Repeat Containing 1 (CTHRC1))

Alternative Name: CTHRC1

Background:

Collagen Triple Helix Repeat-containing Protein 1, NMTC1

Collagen triple helix repeat containing-1 (CTHRC1) is a 30 kDa glycosylated secretory protein containing a short collagen-like motif contributing to vascular remodeling by limiting collagen matrix deposition and promoting cell migration. CTHRC1 is expressed in calcified atherosclerotic plaque and chondrocyte-like cells, in the hypothalamus, pituitary gland and remodeling tissues. Aberrant expression of CTHRC1 is present in human solid cancers and likely to be associated with cancer invasion and metastasis. With adiponectin and other members of the C1q/TNF-related protein (CTRP) family, CTHRC1 shares the presence of a short N-terminal collagen domain but it lacks the characteristic C1q domain that defines the CTRP family of proteins. A recent study identifies CTHRC1 as a novel circulating hormone with metabolic effects.

Molecular Weight: ~Two bands of 25-30 kDa (SDS-PAGE)

UniProt: Q96CG8

Pathways: Tube Formation