Ephrin B3 Protein (EFNB3) (AA 28-227) (His tag)

Catalog No. ABIN5709447

Recombinant Ephrin B3 protein expressed in Escherichia coli (E. coli).

Quick Overview for Ephrin B3 Protein (EFNB3) (AA 28-227) (His tag) (ABIN5709447)

Target: Ephrin B3 (EFNB3)

Protein Type: Recombinant

Origin: Mouse

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Purity: > 90 %

Product Details

Protein Characteristics: AA 28-227

Purification tag / Conjugate: This Ephrin B3 protein is labelled with His tag.

Sequence: LSLEPVYWNS ANKRFQAEGG YVLYPQIGDR LDLLCPRARP PGPHSSPSYE FYKLYLVEGA QGRRCEAPPA PNLLLTCDRP DLDLRFTIKF QEYSPNLWGH EFRSHHDYYI IATSDGTREG LESLQGGVCL TRGMKVLLRV GQSPRGGAVP RKPVSEMPME RDRGAAHSAE PGRDTIPGDP SSNATSRGAE GPLPPPSMPA

Purification: SDS-PAGE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: Ephrin B3 (EFNB3)

Alternative Name: EFNB3

Background: Cell surface transmbrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a pivotal role in forebrain function. Binds to, and induce the collapse of, commissural axons/growth cones in vitro. May play a role in constraining the orientation of longitudinally projecting axons.

Molecular Weight: 26.1 kDa

UniProt: O35393

Pathways: RTK Signaling