KCNAB2 Protein (AA 1-367, full length) (His-SUMO Tag)

Catalog No. ABIN5709787

Product Details

Target: KCNAB2 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, beta Member 2 (KCNAB2))

Protein Type: Recombinant

Protein Characteristics: AA 1-367, full length

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This KCNAB2 protein is labelled with His-SUMO Tag.

Application: SDS-PAGE (SDS)

Sequence: MYPESTTGSP ARLSLRQTGS PGMIYSTRYG SPKRQLQFYR NLGKSGLRVS CLGLGTWVTF GGQITDEMAE QLMTLAYDNG INLFDTAEVY AAGKAEVVLG NIIKKKGWRR SSLVITTKIF WGGKAETERG LSRKHIIEGL KASLERLQLE YVDVVFANRP DPNTPMEETV RAMTHVINQG MAMYWGTSRW SSMEIMEAYS VARQFNLTPP ICEQAEYHMF QREKVEVQLP ELFHKIGVGA MTWSPLACGI VSGKYDSGIP PYSRASLKGY QWLKDKILSE EGRRQQAKLK ELQAIAERLG CTLPQLAIAW CLRNEGVSSV LLGASNADQL MENIGAIQVL PKLSSSIIHE IDSILGNKPY SKKDYRS

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: KCNAB2 (Potassium Voltage-Gated Channel, Shaker-Related Subfamily, beta Member 2 (KCNAB2))

Alternative Name: KCAB2 (KCNAB2 Products)

Synonyms: kcnab2 Protein, KCNAB2 Protein, DKFZp459E056 Protein, akr6a5 Protein, kcna2b Protein, kvb-a Protein, kvb2 Protein, kvbeta2 Protein, kvbeta2.1 Protein, kvbeta2.2 Protein, AKR6A5 Protein, HKvbeta2 Protein, HKvbeta2.1 Protein, HKvbeta2.2 Protein, KCNA2B Protein, KV-BETA-2 Protein, Kvbeta2.1 Protein, F5 Protein, I2rf5 Protein, Kcnb3 Protein, kv-beta-2 Protein, potassium channel, voltage gated subfamily A regulatory beta subunit 1 Protein, potassium voltage-gated channel subfamily A regulatory beta subunit 2 Protein, potassium voltage-gated channel, shaker-related subfamily, beta member 2 a Protein, potassium channel, voltage gated subfamily A regulatory beta subunit 2 L homeolog Protein, voltage-gated potassium channel subunit beta-2 Protein, potassium voltage-gated channel, shaker-related subfamily, beta member 2 Protein, kcnab1 Protein, KCNAB2 Protein, kcnab2a Protein, kcnab2.L Protein, LOC397248 Protein, Kcnab2 Protein

Background: Cytoplasmic potassium channel subunit that modulates the characteristics of the channel-forming alpha-subunits . Contributes to the regulation of nerve signaling, and prevents neuronal hyperexcitability . Promotes expression of the pore-forming alpha subunits at the cell mbrane, and thereby increases channel activity . Promotes potassium channel closure via a mechanism that does not involve physical obstruction of the channel pore . Promotes KCNA4 channel closure . Modulates the functional properties of KCNA5 . Enhances KCNB2 channel activity . Binds NADPH and has NADPH-dependent aldoketoreductase activity . Has broad substrate specificity and can catalyze the reduction of methylglyoxal, 9,10-phenanthrenequinone, prostaglandin J2, 4-nitrobenzaldehyde, 4-nitroacetophenone and 4-oxo-trans-2-nonenal (in vitro) .

Molecular Weight: 56.97 kDa

UniProt: Q13303