POLR3K Protein (AA 1-108, full length) (His-SUMO Tag)
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- Target See all POLR3K Proteins
- POLR3K (Polymerase (RNA) III (DNA Directed) Polypeptide K, 12.3 KDa (POLR3K))
- Protein Type
- Recombinant
- Protein Characteristics
- full length, AA 1-108
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This POLR3K protein is labelled with His-SUMO Tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MLLFCPGCGN GLIVEEGQRC HRFACNTCPY VHNITRKVTN RKYPKLKEVD DVLGGAAAWE NVDSTAESCP KCEHPRAYFM QLQTRSADEP MTTFYKCCNA QCGHRWRD
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product POLR3K Protein
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Polymerase (RNA) III (DNA Directed) Polypeptide K, 12.3 KDa (POLR3K) (AA 1-108) protein (His tag)
POLR3K Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE ELISA, WB
Polymerase (RNA) III (DNA Directed) Polypeptide K, 12.3 KDa (POLR3K) (AA 1-108) protein (GST tag)POLR3K Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Polymerase (RNA) III (DNA Directed) Polypeptide K, 12.3 KDa (POLR3K) (AA 1-108) protein (Strep Tag)Crystallography grade POLR3K Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB
Polymerase (RNA) III (DNA Directed) Polypeptide K, 12.3 KDa (POLR3K) (AA 1-108) protein (Strep Tag)Crystallography grade POLR3K Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB
Polymerase (RNA) III (DNA Directed) Polypeptide K, 12.3 KDa (POLR3K) protein (Myc-DYKDDDDK Tag)POLR3K Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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- Target
- POLR3K (Polymerase (RNA) III (DNA Directed) Polypeptide K, 12.3 KDa (POLR3K))
- Alternative Name
- RPC10 (POLR3K Products)
- Synonyms
- MGC108467 Protein, POLR3K Protein, 12.3kDa Protein, 1500004O14Rik Protein, AI196849 Protein, AU014893 Protein, C11 Protein, RPC10 Protein, RPC11 Protein, C11-RNP3 Protein, RPC12.5 Protein, hRPC11 Protein, RNA polymerase III subunit K Protein, polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa S homeolog Protein, polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa Protein, polymerase (RNA) III (DNA directed) polypeptide K Protein, Polr3k Protein, polr3k.S Protein, polr3k Protein, POLR3K Protein
- Background
- DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as tplate for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway .
- Molecular Weight
- 28.3 kDa
- UniProt
- Q9Y2Y1
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