UBE2V2 Protein (AA 2-145) (His-SUMO Tag)

Catalog No. ABIN5710586

Product Details

Target: UBE2V2 (Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2))

Protein Type: Recombinant

Protein Characteristics: AA 2-145

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This UBE2V2 protein is labelled with His-SUMO Tag.

Application: SDS-PAGE (SDS)

Sequence: AVSTGVKVPR NFRLLEELEE GQKGVGDGTV SWGLEDDEDM TLTRWTGMII GPPRTNYENR IYSLKVECGP KYPEAPPSVR FVTKINMNGI NNSSGMVDAR SIPVLAKWQN SYSIKVVLQE LRRLMMSKEN MKLPQPPEGQ TYNN

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: UBE2V2 (Ubiquitin-Conjugating Enzyme E2 Variant 2 (UBE2V2))

Alternative Name: UB2V2 (UBE2V2 Products)

Synonyms: DDVIT1 Protein, DDVit-1 Protein, EDAF-1 Protein, EDPF-1 Protein, EDPF1 Protein, MMS2 Protein, UEV-2 Protein, UEV2 Protein, mms2 Protein, uev2 Protein, edpf1 Protein, uev-2 Protein, ddvit1 Protein, edaf-1 Protein, edpf-1 Protein, ddvit-1 Protein, 1110021H13Rik Protein, 4632410D19Rik Protein, 5730524P06Rik Protein, 6820402M05 Protein, AI848315 Protein, C81524 Protein, wu:fb18b11 Protein, wu:fb24d11 Protein, zgc:63717 Protein, UBE2V2 Protein, TMEM189-UBE2V1 Protein, ubiquitin conjugating enzyme E2 V2 Protein, ubiquitin-conjugating enzyme E2 variant 2 Protein, ubiquitin conjugating enzyme E2 V2 S homeolog Protein, Ubiquitin-conjugating enzyme E2 variant 2 Protein, UBE2V2 Protein, Ube2v2 Protein, ube2v2 Protein, ube2v2.S Protein, PTRG_00824 Protein, ub2v2 Protein, Tsp_08004 Protein

Background: Has no ubiquitin ligase activity on its own. The UBE2V2/UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through 'Lys-63'. This type of poly-ubiquitination does not lead to protein degradation by the proteasome. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage.

Molecular Weight: 32.2 kDa

UniProt: Q15819

Pathways: Positive Regulation of Response to DNA Damage Stimulus