TR4 Protein (AA 3-592, partial) (His tag)

Catalog No. ABIN5713012

Product Details

Target: TR4 (NR2C2) (Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2))

Protein Type: Recombinant

Protein Characteristics: AA 3-592, partial

Origin: Mouse

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This TR4 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: SPSPRIQIIS TDSAVASPQR IQIVTDQQTG QKIQIVTAVD ASGSPKQQFI LTSPDGAGTG KVILASPETS SAKQLIFTTS DNLVPGRIQI VTDSASVERL LGKTDVQRPQ VVEYCVVCGD KASGRHYGAV SCEGCKGFFK RSVRKNLTYS CRSNQDCIIN KHHRNRCQFC RLKKCLEMGM KMESVQSERK PFDVQREKPS NCAASTEKIY IRKDLRSPLI ATPTFVADKD GARQTGLLDP GMLVNIQQPL IREDGTVLLA TDSKAETSQG ALGTLANVVT SLANLSESLN NGDTSEIQPE DQSASEITRA FDTLAKALNT TDSSSSPSLA DGIDTSGGGS IHVISRDQST PIIEVEGPLL SDTHVTFKLT MPSPMPEYLN VHYICESASR LLFLSMHWAR SIPAFQALGQ DCNTSLVRAC WNELFTLGLA QCAQVMSLST ILAAIVNHLQ NSIQEDKLSG DRIKQVMEHI WKLQEFCNSM AKLDIDGYEY AYLKAIVLFS PDHPGLTSTS QIEKFQEKAQ MELQDYVQKT YSEDTYRLAR ILVRLPALRL MSSNITEELF FTGLIGNVSI DSIIPYILKM ETAEYNGQIT

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: TR4 (NR2C2) (Nuclear Receptor Subfamily 2, Group C, Member 2 (NR2C2))

Alternative Name: NR2C2 (NR2C2 Products)

Synonyms: TAK1 Protein, TR2R1 Protein, TR4 Protein, hTAK1 Protein, Tr4 Protein, gb:dq017625 Protein, im:6911408 Protein, mKIAA4145 Protein, nuclear receptor subfamily 2 group C member 2 Protein, nuclear receptor subfamily 2, group C, member 2 Protein, NR2C2 Protein, Nr2c2 Protein, nr2c2 Protein

Background: Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during expression during the late phase of spermatogenesis. Activates transcriptional activity of LHCG and is antagonist of PPARA-mediated transactivation . Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses bryonic and fetal globin transcription including that of GATA1. Binds to hormone response elents (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early bryonic development and bryonic st cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior

Molecular Weight: 68.9 kDa

UniProt: P49117

Pathways: TCR Signaling, Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Production of Molecular Mediator of Immune Response, Tube Formation, Toll-Like Receptors Cascades