MICAL2 Protein (AA 1-495, partial) (His tag)

Catalog No. ABIN5713642

Product Details

Target: MICAL2 (Microtubule Associated Monoxygenase, Calponin and LIM Domain Containing 2 (MICAL2))

Protein Type: Recombinant

Protein Characteristics: AA 1-495, partial

Origin: Human

Source: Yeast

Purification tag / Conjugate: This MICAL2 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: MGENEDEKQA QAGQVFENFV QASTCKGTLQ AFNILTRHLD LDPLDHRNFY SKLKSKVTTW KAKALWYKLD KRGSHKEYKR GKSCTNTKCL IVGGGPCGLR TAIELAYLGA KVVVVEKRDS FSRNNVLHLW PFTIHDLRGL GAKKFYGKFC AGSIDHISIR QLQLILFKVA LMLGVEIHVN VEFVKVLEPP EDQENQKIGW RAEFLPTDHS LSEFEFDVII GADGRRNTLE GFRRKEFRGK LAIAITANFI NRNSTAEAKV EEISGVAFIF NQKFFQDLKE ETGIDLENIV YYKDCTHYFV MTAKKQSLLD KGVIINDYID TEMLLCAENV NQDNLLSYAR EAADFATNYQ LPSLDFAMNH YGQPDVAMFD FTCMYASENA ALVRERQAHQ LLVALVGDSL LEPFWPMGTG CARGFLAAFD TAWMVKSWNQ GTPPLELLAE RESLYRLLPQ TTPENINKNF EQYTLDPGTR YPNLNSHCVR PHQVKHLYIT KELEH

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: MICAL2 (Microtubule Associated Monoxygenase, Calponin and LIM Domain Containing 2 (MICAL2))

Alternative Name: MICA2 (MICAL2 Products)

Synonyms: MICAL-2 Protein, MICAL2PV1 Protein, MICAL2PV2 Protein, 5330438E18Rik Protein, 9530064J02 Protein, mKIAA0750 Protein, RGD1311773 Protein, microtubule associated monooxygenase, calponin and LIM domain containing 2 Protein, MICAL2 Protein, Mical2 Protein

Background: Nuclear monooxygenase that promotes depolymerization of F-actin by mediating oxidation of specific methionine residues on actin and regulates the SRF signaling. Acts by modifying nuclear actin subunits through the addition of oxygen to form methionine-sulfoxide, leading to promote actin filament severing and prevent repolymerization. Acts as a key regulator of the SRF signaling pathway elicited by nerve growth factor and serum: mediates oxidation and subsequent depolymerization of nuclear actin, leading to increase MKL1/MRTF-A presence in the nucleus and promote SRF:MKL1/MRTF-A-dependent gene transcription. Does not activate SRF:MKL1/MRTF-A through RhoA.

Molecular Weight: 58.48 kDa

UniProt: O94851