SMARCA2 Protein (AA 700-1216, partial) (His tag)

Catalog No. ABIN5713844

Product Details

Target: SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2))

Protein Type: Recombinant

Protein Characteristics: partial, AA 700-1216

Origin: Human

Source: Yeast

Purification tag / Conjugate: This SMARCA2 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: SYYTVAHAIS ERVEKQSALL INGTLKHYQL QGLEWMVSLY NNNLNGILAD EMGLGKTIQT IALITYLMEH KRLNGPYLII VPLSTLSNWT YEFDKWAPSV VKISYKGTPA MRRSLVPQLR SGKFNVLLTT YEYIIKDKHI LAKIRWKYMI VDEGHRMKNH HCKLTQVLNT HYVAPRRILL TGTPLQNKLP ELWALLNFLL PTIFKSCSTF EQWFNAPFAM TGERVDLNEE ETILIIRRLH KVLRPFLLRR LKKEVESQLP EKVEYVIKCD MSALQKILYR HMQAKGILLT DGSEKDKKGK GGAKTLMNTI MQLRKICNHP YMFQHIEESF AEHLGYSNGV INGAELYRAS GKFELLDRIL PKLRATNHRV LLFCQMTSLM TIMEDYFAFR NFLYLRLDGT TKSEDRAALL KKFNEPGSQY FIFLLSTRAG GLGLNLQAAD TVVIFDSDWN PHQDLQAQDR AHRIGQQNEV RVLRLCTVNS VEEKILAAAK YKLNVDQKVI QAGMFDQKSS SHERRAF

Purification: SDS-PAGE

Purity: > 90 %

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 0.1-2 mg/mL

Buffer: 20 mM Tris-HCl based buffer, pH 8.0

Storage: -80 °C,4 °C,-20 °C

Storage Comment: Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.

Target Details

Target: SMARCA2 (SWI/SNF Related, Matrix Associated, Actin Dependent Regulator of Chromatin, Subfamily A, Member 2 (SMARCA2))

Alternative Name: SMCA2 (SMARCA2 Products)

Synonyms: BAF190 Protein, BRM Protein, NCBRS Protein, SNF2 Protein, SNF2L2 Protein, SNF2LA Protein, SWI2 Protein, Sth1p Protein, hBRM Protein, hSNF2a Protein, brm Protein, 2610209L14Rik Protein, SNF2alpha Protein, Snf2l2 Protein, brahma Protein, psa-4 Protein, wu:fa56c07 Protein, wu:fi27f11 Protein, zgc:66238 Protein, Brahma Protein, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 Protein, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2 L homeolog Protein, SMARCA2 Protein, smarca2.L Protein, Smarca2 Protein, smarca2 Protein

Background: Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Belongs to the neural progenitors-specific chromatin rodeling complex (npBAF complex) and the neuron-specific chromatin rodeling complex (nBAF complex). During neural development a switch from a st/progenitor to a postmitotic chromatin rodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural st/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural st cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth .

Molecular Weight: 61.7 kDa

UniProt: P51531