BRAP Protein (AA 1-592, full length) (His tag)
-
- Target See all BRAP Proteins
- BRAP (BRCA1 Associated Protein (BRAP))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-592, full length
-
Origin
- Human
-
Source
- Yeast
- Purification tag / Conjugate
- This BRAP protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MSVSLVVIRL ELAEHSPVPA GFGFSAAAGE MSDEEIKKTT LASAVACLEG KSPGEKVAII HQHLGRREMT DVIIETMKSN PDELKTTVEE RKSSEASPTA QRSKDHSKEC INAAPDSPSK QLPDQISFFS GNPSVEIVHG IMHLYKTNKM TSLKEDVRRS AMLCILTVPA AMTSHDLMKF VAPFNEVIEQ MKIIRDSTPN QYMVLIKFRA QADADSFYMT CNGRQFNSIE DDVCQLVYVE RAEVLKSEDG ASLPVMDLTE LPKCTVCLER MDESVNGILT TLCNHSFHSQ CLQRWDDTTC PVCRYCQTPE PVEENKCFEC GVQENLWICL ICGHIGCGRY VSRHAYKHFE ETQHTYAMQL TNHRVWDYAG DNYVHRLVAS KTDGKIVQYE CEGDTCQEEK IDALQLEYSY LLTSQLESQR IYWENKIVRI EKDTAEEINN MKTKFKETIE KCDNLEHKLN DLLKEKQSVE RKCTQLNTKV AKLTNELKEE QEMNKCLRAN QVLLQNKLKE EERVLKETCD QKDLQITEIQ EQLRDVMFYL ETQQKINHLP AETRQEIQEG QINIAMASAS SPASSGGSGK LPSRKGRSKR GK
- Purification
- SDS-PAGE
- Purity
- > 90 %
- Top Product
- Discover our top product BRAP Protein
-
BRCA1 Associated Protein (BRAP) (AA 1-592) protein (Strep Tag)
Crystallography grade BRAP Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
BRCA1 Associated Protein (BRAP) (AA 1-591) protein (Strep Tag)Crystallography grade BRAP Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, ELISA, WB
BRCA1 Associated Protein (BRAP) protein (His tag)BRAP Origin: Human Host: Escherichia coli (E. coli) Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
-
- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
-
- Format
- Liquid
- Concentration
- 0.1-2 mg/mL
- Buffer
- 20 mM Tris-HCl based buffer, pH 8.0
- Storage
- -80 °C,4 °C,-20 °C
- Storage Comment
- Store at -20°C, for extended storage, conserve at -20°C or -80°C. Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
-
- Target
- BRAP (BRCA1 Associated Protein (BRAP))
- Alternative Name
- BRAP (BRAP Products)
- Synonyms
- imp Protein, MGC68778 Protein, zgc:92894 Protein, BRAP Protein, BRAP2 Protein, IMP Protein, RNF52 Protein, 3010002G07Rik Protein, BRCA1 associated protein S homeolog Protein, BRCA1 associated protein Protein, BRCA1-associated protein Protein, brca1-associated protein Protein, brap.S Protein, brap Protein, BRAP Protein, NAEGRDRAFT_81654 Protein, CC1G_00971 Protein, CpipJ_CPIJ003557 Protein, Tsp_05101 Protein, LOC100282389 Protein, Brap Protein
- Background
- Negatively regulates MAP kinase activation by limiting the formation of Raf/MEK complexes probably by inactivation of the KSR1 scaffold protein. Also acts as a Ras responsive E3 ubiquitin ligase that, on activation of Ras, is modified by auto-polyubiquitination resulting in the release of inhibition of Raf/MEK complex formation. May also act as a cytoplasmic retention protein with a role in regulating nuclear transport.
- Molecular Weight
- 69.3 kDa
- UniProt
- Q7Z569
-
