Prohibitin 2 Protein (PHB2) (AA 1-299) (His tag)

Catalog No. ABIN5853059

Product Details

Target: Prohibitin 2 (PHB2)

Protein Type: Recombinant

Protein Characteristics: AA 1-299

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This Prohibitin 2 protein is labelled with His tag.

Application: SDS-PAGE (SDS)

Sequence: MGSSHHHHHH SSGLVPRGSH MGSMAQNLKD LAGRLPAGPR GMGTALKLLL GAGAVAYGVR ESVFTVEGGH RAIFFNRIGG VQQDTILAEG LHFRIPWFQY PIIYDIRARP RKISSPTGSK DLQMVNISLR VLSRPNAQEL PSMYQRLGLD YEERVLPSIV NEVLKSVVAK FNASQLITQR AQVSLLIRRE LTERAKDFSL ILDDVAITEL SFSREYTAAV EAKQVAQQEA QRAQFLVEKA KQEQRQKIVQ AEGEAEAAKM LGEALSKNPG YIKLRKIRAA QNISKTIATS QNRIYLTADN LVLNLQDESF TRGSDSLIKG KK

Purity: > 85 % by SDS - PAGE

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Comment:

Denatured

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Liquid. In 20  mM Tris-HCl buffer (  pH 8.0) containing 0.4M uREA, 10 % glycerol

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.

Target Details

Target: Prohibitin 2 (PHB2)

Alternative Name: PHB2 (PHB2 Products)

Synonyms: bcap37 Protein, zgc:73150 Protein, wu:fc28c08 Protein, PHB2 Protein, phb2 Protein, ATPHB2 Protein, F21M11.21 Protein, F21M11_21 Protein, prohibitin 2 Protein, DKFZp469N1310 Protein, BAP Protein, BCAP37 Protein, Bap37 Protein, PNAS-141 Protein, REA Protein, p22 Protein, bap37 Protein, prohibitin2 Protein, xphb2 Protein, AU044498 Protein, Bcap37 Protein, Bap Protein, Bap-37 Protein, Bcap27 Protein, prohibitin 2a Protein, prohibitin 2 Protein, prohibitin 2 S homeolog Protein, phb2a Protein, PHB2 Protein, phb2 Protein, phb2.S Protein, Phb2 Protein

Background: PHB2 acts as a mediator of transcriptional repression by nuclear hormone receptors via recruitment of histone deacetylases by similarity. This protein functions as an estrogen receptor (ER)-selective coregulator that potentiates the inhibitory activities of antiestrogens and represses the activity of estrogens. PHB2 competes with NCOA1 for modulation of ER transcriptional activity. It is probably involved in regulating mitochondrial respiration activity and in aging. Recombinant human PHB2 protein, fused to His-tag at N-terminus, was expressed in E.coli.

Molecular Weight: 35.7 kDa (322aa)

NCBI Accession: NP_001138303

UniProt: Q99623

Pathways: Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling