IYD Protein (AA 24-214) (His tag)
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- Target See all IYD Proteins
- IYD (Iodotyrosine Deiodinase (IYD))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 24-214
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This IYD protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MGSDRSMEKK KGEPRTRAEA RPWVDEDLKD SSDLHQAEED ADEWQESEEN VEHIPFSHNH YPEKEMVKRS QEFYELLNKR RSVRFISNEQ VPMEVIDNVI RTAGTAPSGA HTEPWTFVVV KDPDVKHKIR KIIEEEEEIN YMKRMGHRWV TDLKKLRTNW IKEYLDTAPI LILIFKQVHG FAANGKKKVH YYNE
- Purity
- > 90 % by SDS - PAGE
- Top Product
- Discover our top product IYD Protein
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Iodotyrosine Deiodinase (IYD) (AA 1-289) protein (GST tag)
IYD Origin: Human Host: Wheat germ Recombinant ELISA, WB, AP, AA
Iodotyrosine Deiodinase (IYD) (AA 24-214) protein (His tag)Crystallography grade IYD Origin: Human Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB, Crys
Iodotyrosine Deiodinase (IYD) (AA 24-210) protein (His tag)Crystallography grade IYD Origin: Mouse Host: Escherichia coli (E. coli) Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB, Crys
Iodotyrosine Deiodinase (IYD) (AA 24-289) protein (rho-1D4 tag)Crystallography grade IYD Origin: Human Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB, Crys
Iodotyrosine Deiodinase (IYD) (AA 24-285) protein (rho-1D4 tag)Crystallography grade IYD Origin: Mouse Host: Insect Cells Recombinant >95 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. ELISA, SDS, WB, Crys
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Comment
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Denatured
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.4M uREA, 10 % glycerol
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- IYD (Iodotyrosine Deiodinase (IYD))
- Alternative Name
- IYD (IYD Products)
- Synonyms
- MGC85450 Protein, C6orf71 Protein, DEHAL1 Protein, TDH4 Protein, dJ422F24.1 Protein, 0610009A07Rik Protein, AI265638 Protein, Dehal1 Protein, RGD1309288 Protein, IYD-1 Protein, iodotyrosine deiodinase Protein, iodotyrosine deiodinase L homeolog Protein, IYD Protein, iyd.L Protein, iyd Protein, Iyd Protein
- Background
- IYD is an enzyme that catalyzes the oxidative NADPH-dependent deiodination of mono- and diiodotyrosine, which are the halogenated byproducts of thyroid hormone production. The N-terminus of the protein functions as a membrane anchor. Mutations in this gene cause congenital hypothyroidism due to dyshormonogenesis type 4, which is also referred to as deiodinase deficiency, or iodotyrosine dehalogenase deficiency, or thyroid hormonogenesis type 4. Alternative splicing results in multiple transcript variants. Recombinant human IYD protein, fused to His-tag at N-terminus, was expressed in E.coli.
- Molecular Weight
- 25.1kDa (214aa)
- NCBI Accession
- NP_001158167
- UniProt
- Q6PHW0
- Pathways
- Thyroid Hormone Synthesis
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