Granulin Protein (GRN) (DYKDDDDK Tag)

Catalog No. ABIN622274

This Recombinant Granulin protein is expressed in .

Quick Overview for Granulin Protein (GRN) (DYKDDDDK Tag) (ABIN622274)

Target: Granulin (GRN)

Protein Type: Recombinant

Origin: Human

Host: Please inquire

Purity: > 90.0 % as determined by: a) Analysis by RP-HPLC. b) Analysis by SDS-PAGE.

Product Details

Purification tag / Conjugate: This Granulin protein is labelled with DYKDDDDK Tag.

Characteristics: Recombinant Human Progranulin

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: The protein solution contains 1x PBS.

Storage: -20 °C

Target Details

Target: Granulin (GRN)

Alternative Name: Progranulin

Target Type: Viral Protein

Background: Progranulin Human Recombinant fused to DYKDDDDK at C-terminus produced in HEK is a single, glycosylated, polypeptide chain containing 593 AA and having a molecular mass of 88 kDa. The Progranulin is purified by standard chromatographic techniques. Introduction: A 88 kDa progranulin, also called proepithelin and PC cell-derived growth factor, is a single precursor protein of granulins which are a family of secreted, glycosylated peptides that are cleaved from a single precursor protein with 7.5 repeats of a highly conserved 12-cysteine granulin/epithelin motif. Granulins are a variety of active, 6 kDa peptides and named granulin A (epithelin 1), granulin B (epithelin 2), granulin C, etc. Both the peptides and intact progranulin protein regulate cell growth. However, different members of the granulin protein family may act as inhibitors, stimulators, or have dual actions on cell growth. Granulin family members are important in normal development, wound healing, and tumorigenesis. Synonyms: GRN, PGRN, granulin, Acrogranin, propithelin, PC cell derived growth Factor, GEP, GP88, PEPI, PCDGF.