DUSP6 Protein (AA 1-381) (His tag)
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- Target See all DUSP6 Proteins
- DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 1-381
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This DUSP6 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Sequence
- MGSSHHHHHH SSGLVPRGSH MIDTLRPVPF ASEMAISKTV AWLNEQLELG NERLLLMDCR PQELYESSHI ESAINVAIPG IMLRRLQKGN LPVRALFTRG EDRDRFTRRC GTDTVVLYDE SSSDWNENTG GESVLGLLLK KLKDEGCRAF YLEGGFSKFQ AEFSLHCETN LDGSCSSSSP PLPVLGLGGL RISSDSSSDI ESDLDRDPNS ATDSDGSPLS NSQPSFPVEI LPFLYLGCAK DSTNLDVLEE FGIKYILNVT PNLPNLFENA GEFKYKQIPI SDHWSQNLSQ FFPEAISFID EARGKNCGVL VHCLAGISRS VTVTVAYLMQ KLNLSMNDAY DIVKMKKSNI SPNFNFMGQL LDFERTLGLS SPCDNRVPAQ QLYFTTPSNQ NVYQVDSLQS T
- Purity
- > 85 % by SDS - PAGE
- Top Product
- Discover our top product DUSP6 Protein
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Dual Specificity Phosphatase 6 (DUSP6) (AA 1-381) protein (His tag)
DUSP6 Origin: Human Host: Escherichia coli (E. coli) Recombinant Greater than 95 % as determined by SDS-PAGE WB, ELISA
Dual Specificity Phosphatase 6 (DUSP6) (AA 1-381) protein (GST tag)DUSP6 Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
Dual Specificity Phosphatase 6 (DUSP6) (AA 1-381) protein (Strep Tag)Crystallography grade DUSP6 Origin: Human Host: Tobacco (Nicotiana tabacum) Recombinant >80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Dual Specificity Phosphatase 6 (DUSP6) (AA 1-381) protein (Strep Tag)Crystallography grade DUSP6 Origin: Mouse Host: Tobacco (Nicotiana tabacum) Recombinant ≥ 80 % as determined by SDS PAGE, Size Exclusion Chromatography and Western Blot. SDS, WB, ELISA
Dual Specificity Phosphatase 6 (DUSP6) (Transcript Variant 1) protein (Myc-DYKDDDDK Tag)DUSP6 Origin: Human Host: HEK-293 Cells Recombinant > 80 % as determined by SDS-PAGE and Coomassie blue staining AbP, STD
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- Application Notes
- Optimal working dilution should be determined by the investigator.
- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 0.25 mg/mL
- Buffer
- Liquid. In 20 mM Tris-HCl buffer ( pH 8.0) containing 0.15M NaCl, 10 % glycerol, 1 mM DTT
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Can be stored at +4C short term (1-2 weeks). For long term storage, aliquot and store at -20C or -70C. Avoid repeated freezing and thawing cycles.
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- Target
- DUSP6 (Dual Specificity Phosphatase 6 (DUSP6))
- Alternative Name
- DuSP6 (DUSP6 Products)
- Synonyms
- HH19 Protein, MKP3 Protein, PYST1 Protein, 1300019I03Rik Protein, MKP-3 Protein, Mkp3 Protein, wu:fd99d09 Protein, mkp3 Protein, pyst1 Protein, DUSP6 Protein, dusp6 Protein, dual specificity phosphatase 6 Protein, dual specificity phosphatase 6 L homeolog Protein, Dual specificity protein phosphatase 6 Protein, DUSP6 Protein, Dusp6 Protein, dusp6 Protein, dusp6.L Protein, dus6 Protein
- Background
- DuSP6 is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. Recombinant human DuSP6 protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.
- Molecular Weight
- 44.4 kDa (401aa) confirmed by MALDI-TOF
- NCBI Accession
- NP_001937
- UniProt
- Q16828
- Pathways
- Neurotrophin Signaling Pathway, Activation of Innate immune Response, Toll-Like Receptors Cascades
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