Neutrophil Migration (NM) (AA 22-255) Protein

Catalog No. ABIN666806

Product Details

Target: Neutrophil Migration (NM)

Protein Type: Recombinant

Protein Characteristics: AA 22-255

Origin: Human

Source: Escherichia coli (E. coli)

Application: SDS-PAGE (SDS)

Characteristics: NCR, NKp46 ( Extracellular Ig-like domain , 22-255aa, human), Recombinant, E.coli

Purity: > 95 % by SDS - PAGE

Application Details

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/ml (determined by Bradford assay)

Buffer: Liquid. In phosphate buffered saline (pH7.4), 1mM EDTA

Storage: 4 °C

Target Details

Target: Neutrophil Migration (NM)

Alternative Name: NCR

Synonyms: GP130 Protein, NCR Protein, neutrophil migration Protein, NM Protein

Background: A natural cytotoxicity receptor(NCR) NKp46 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. The natural cytotoxicity receptors(NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. The three known NCRs include NKp46 and NKp30,which are expressed on circulating NKcells, and NKp44,which is expressed only on activating NK cells. NKp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells and pathogen-infected cell lines. NKp46 has two extracellular Ig-like domains followed by a ~40 residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. The extracellular Ig-like domain of NKp46( 22-255aa) was overexpressed in E.coli, and purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer. Synonyms: NCR1, LY94, NCR, NKp46 Extracellular Ig-like domain, Natural killer cell p46-related protein, hNKp46, NK-p46, NKp46, NK cell-activating receptor, Lymphocyte antigen 94 homolog, CD335 antigen, Natural cytotoxicity triggering receptor 1, Natural cytotoxicity triggering receptor 1 isoform a. NCBI no.: NP_004820

Molecular Weight: 26.6 kDa (235 aa), confirmed by MALDI-TOF.