KIR3DL1 Protein (AA 361-444) (His tag)
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- Target See all KIR3DL1 products
- KIR3DL1 (Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 1 (KIR3DL1))
- Protein Type
- Recombinant
- Protein Characteristics
- AA 361-444
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Origin
- Human
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Source
- Escherichia coli (E. coli)
- Purification tag / Conjugate
- This KIR3DL1 protein is labelled with His tag.
- Application
- SDS-PAGE (SDS)
- Characteristics
- KIR3DL1(Cytoplasmic tail, 361-444aa, His-tag , Human), Recombinant, E.coli
- Purity
- > 95 % by SDS - PAGE
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- Restrictions
- For Research Use only
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- Format
- Liquid
- Concentration
- 1 mg/ml (determined by Bradford assay)
- Buffer
- Liquid. In 25 mM Tris-HCl (pH7.5) 100mM NaCl
- Storage
- 4 °C
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- Target
- KIR3DL1 (Killer Cell Immunoglobulin-Like Receptor, three Domains, Long Cytoplasmic Tail, 1 (KIR3DL1))
- Abstract
- KIR3DL1 Products
- Synonyms
- KIR3DL1 Protein, KIR3DL3 Protein, CD158E1 Protein, KIR Protein, KIR3DL1/S1 Protein, NKAT3 Protein, NKB1 Protein, NKB1B Protein, Kirl1 Protein, Kirl2 Protein, Krl1 Protein, killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1 Protein, uncharacterized LOC100437736 Protein, killer cell immunoglobulin like receptor, three Ig domains and long cytoplasmic tail 1 Protein, KIR3DL1 Protein, LOC100437736 Protein, Kir3dl1 Protein
- Background
- The three Ig-domain from of inhibitory killer cell Ig-like receptor 1(KIR3DL1,NKB1, nkat3, p70KIR) is a NK cell receptor for polymorphic HLA-B determinant. KIR3DLl recognizes the Bw4 determinant defined by sequence motifs at positins 77-83 of the HLA-B heavy chain. The cytoplasmic tail of KIR, which contains two immunoreceptor tyrosine-based inhibition motifs(ITIMs), mediates inhibitory signal transduction that prevents killer cell-mediated cytotoxicity. A His-tag fusion protein of KIR3DL1 cytoplasmic tail(361-444aa) was overexpressed as insoluble protein aggregates(inclusion bodies). This protein was purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer. Synonyms: KIR3DL1, CD158E, NKAT3, NKB1, KIR3DL1 (Cytoplasmic tail, 361-444aa), MHC class I NK cell receptor, Natural killer-associated transcript 3, NKAT-3, p70 natural killer cell receptor clones CL-2/CL-11, HLA-BW4-specific inhibitory NK cell receptor, CD1, Killer cell immunoglobulin-like receptor 3DL1, Killer cell immunoglobulin-like receptor 3DL1 AMB11, CD158 antigen-like family member E, CD158e antigen, CD158E1, CD158E1/2, CD158E2, CL11, CL2, HLA-BW4-specific inhibitory NK cell receptor, killer cell immunoglobulin like receptor, Killer cell immunoglobulin like receptor three domains , short cytoplasmic tail, 1, Killer cell immunoglobulin like receptor three domains long cytoplasmic tail 1, KIR, KIR antigen 3DL1, KIR G1, KIR3DS1, Kirl1, Kirl2, Krl1, MGC119726, MGC119728, MGC126589, MGC126591, Natural killer associated transcript 3, Natural killer cell inhibitory receptor, NK receptor, NK-associated transcript 10, NK-associated transcript 3, NK-associated transcript 3delIg1, NKAT10, NKB1B, p70 killer cell inhibitory receptor,. NCBI no.: NP_037421
- Molecular Weight
- 15 kDa (132 aa), confirmed by MALDI-TOF.
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