ACPP Protein (His tag)

Catalog No. ABIN7320069

Product Details

Target: ACPP (Acid Phosphatase, Prostate (ACPP))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This ACPP protein is labelled with His tag.

Purpose: Recombinant Mouse Prostatic Acid Phosphatase/ACPP Protein (His Tag)

Sequence: Met1-Arg 381

Characteristics: A DNA sequence encoding the mouse ACPP isoform 1 (Q8CE08-1) (Met1-Arg 381) was expressed, with a C-terminal polyhistidine tag.

Purity: > 98 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: ACPP (Acid Phosphatase, Prostate (ACPP))

Alternative Name: Prostatic Acid Phosphatase/ACPP (ACPP Products)

Synonyms: 5'-NT Protein, ACP-3 Protein, ACP3 Protein, PAP Protein, AMAP2 Protein, CENTB3 Protein, DDEF2 Protein, PAG3 Protein, Pap-alpha Protein, SHAG1 Protein, A030005E02Rik Protein, FRAP Protein, Lap Protein, Ppal Protein, Acpp11 Protein, RNACPP11 Protein, pap Protein, ACPP Protein, acp-3 Protein, acp3 Protein, acpt Protein, acid phosphatase, prostate Protein, ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 Protein, prostatic acid phosphatase Protein, prostatic acid phosphatase, putative Protein, acid phosphatase, prostate S homeolog Protein, ACPP Protein, ASAP2 Protein, Acpp Protein, CpipJ_CPIJ004002 Protein, Smp_016640 Protein, acpp.S Protein

Background:

Background: Prostatic acid phosphatase (PAP, or ACPP), also known as prostatic specific acid phosphatase (PSAP), is an enzyme produced by the prostate. As a non-specific phosphomonoesterase, Prostatic acid phosphatase synthetized and secreted into seminal plasma under androgenic control. The enzyme is a dimer of molecular weight around 100 kDa. Prostatic acid phosphatase is a clinically important protein for its relevance as a biomarker of prostate carcinoma. Furthermore, it has a potential role in fertilization. The major action of PAP is to dephosphorylate macromolecules with the help of catalytic residues (His(12) and Asp(258)) that are located in the cleft between two domains. Cellular prostatic acid phosphatase (cPAcP), an authentic tyrosine phosphatase, is proposed to function as a negative growth regulator of prostate cancer (PCa) cells in part through its dephosphorylation of ErbB-2. cPAcP functions as a neutral protein tyrosine phosphatase (PTP) in prostate cancer cells and dephosphorylates HER-2/ErbB-2/Neu (HER-2: human epidermal growth factor receptor-2) at the phosphotyrosine (p-Tyr) residues. Injection of the secretory isoform of PAP has potent antinociceptive effects in mouse models of chronic pain. This enzyme exhibits ecto-5'-nucleotidase activity, is widely distributed, and implicated in the formation of chronic pain. Additionally, PAP could be a target molecule in specific immunotherapy for patients with nonprostate adenocarcinomas including colon and gastric cancers.

Synonym: 5'-NT,9.104100899-104272570.1,A030005E02Rik,FRAP,Lap,PAP,Ppal

Molecular Weight: 42 kDa

Pathways: Synaptic Membrane, Ribonucleoside Biosynthetic Process