ART4 Protein (Fc Tag)

Catalog No. ABIN7320049

Product Details

Target: ART4 (ADP-Ribosyltransferase 4 (Dombrock Blood Group) (ART4))

Protein Type: Recombinant

Origin: Mouse

Source: HEK-293 Cells

Purification tag / Conjugate: This ART4 protein is labelled with Fc Tag.

Purpose: Recombinant Mouse ART4/CD297 Protein (Fc Tag)

Sequence: Met1-Lys263

Characteristics: A DNA sequence encoding the mouse Art4 (NP_080915.1) (Met1-Lys263) was expressed, fused with the Fc region of human IgG1 at the C-terminus.

Purity: > 91 % as determined by SDS-PAGE

Endotoxin Level: < 1.0 EU per μg of the protein as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from sterile PBS, pH 7.4

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: ART4 (ADP-Ribosyltransferase 4 (Dombrock Blood Group) (ART4))

Alternative Name: ART4/CD297 (ART4 Products)

Synonyms: ARTC4 Protein, CD297 Protein, DO Protein, DOK1 Protein, ATR4 Protein, 4432404K01Rik Protein, Dombrock Protein, ADP-ribosyltransferase 4 (Dombrock blood group) Protein, ADP-ribosyltransferase 4 Protein, ART4 Protein, Art4 Protein

Background:

Background: ADP-ribosyltransferase 4 (Dombrock blood group), also known as Mono-ADP-ribosyltransferase 4(ART4), Dombrock blood group carrier molecule and CD297, is a protein that contains a mono-ADP-ribosylation (ART) motif. It is a member of the ADP-ribosyltransferase gene family but enzymatic activity has not been demonstrated experimentally. ADP-ribosyltransferase catalyzes the ADP-ribosylation of arginine residues in proteins. Mono-ADP-ribosylation is a posttranslational modification of proteins that is interfered with by a variety of bacterial toxins including cholera, pertussis, and heat-labile enterotoxins of E. coli. ART4 could be detected on HEL cells and erythrocytes by FACS analysis while it was absent from activated monocytes, despite the presence of ART4 mRNA in these cells. ART is also known as the carrier of the Dombrock blood group alloantigens (Do) which is glycosylphosphatidylinosotol-anchored to the erythrocyte membrane.

Synonym: 4432404K01Rik,ARTC4,DO,DOK1

Molecular Weight: 53.7 kDa

NCBI Accession: NP_080915