Iba1 Protein (His tag)

Catalog No. ABIN7318148

Product Details

Target: Iba1 (IBA1) (Ionized Calcium-binding Adapter Molecule 1 (IBA1))

Protein Type: Recombinant

Origin: Human

Source: Escherichia coli (E. coli)

Purification tag / Conjugate: This Iba1 protein is labelled with His tag.

Purpose: Recombinant Human AIF1 Protein (His Tag)

Sequence: Ser2-Pro147

Characteristics: Recombinant Human Allograft Inflammatory Factor 1 is produced by our E.coli expression system and the target gene encoding Ser2-Pro147 is expressed with a 6His tag at the C-terminus.

Purity: > 90 % as determined by reducing SDS-PAGE.

Endotoxin Level: < 1.0 EU per μg as determined by the LAL method.

Application Details

Restrictions: For Research Use only

Handling

Format: Lyophilized

Reconstitution: Please refer to the printed manual for detailed information.

Buffer: Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.

Storage: 4 °C,-20 °C,-80 °C

Storage Comment: Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

Target Details

Target: Iba1 (IBA1) (Ionized Calcium-binding Adapter Molecule 1 (IBA1))

Alternative Name: AIF1 (IBA1 Products)

Synonyms: AIF-1 Protein, IBA1 Protein, IRT-1 Protein, IRT1 Protein, AI607846 Protein, D17H6S50E Protein, G1 Protein, Iba1 Protein, Bart1 Protein, iba1 Protein, mrf-1 Protein, fa04b11 Protein, wu:fa04b11 Protein, AIF Protein, AIF1 Protein, aif1 Protein, allograft inflammatory factor 1 Protein, AIF1 Protein, Aif1 Protein, aif1 Protein

Background:

Background: Allograft Inflammatory Factor 1 (AIF1) contains two EF-hand domains and exists as a homodimer. AIF1 can be detected in T-lymphocytes and peripheral blood mononuclear cells. AIF1 functions as actin-binding protein that enhances membrane ruffling and RAC activation and can enhance the actin-bundling activity of LCP1. In addition, AIF1 plays a role in RAC signaling and in phagocytosis and may also in macrophage activation and function. AIF1 promotes the proliferation of vascular smooth muscle cells and of T-lymphocytes and plays a role in vascular inflammation.

Synonym: Allograft Inflammatory Factor 1, AIF-1, Ionized Calcium-Binding Adapter Molecule 1, Protein G1, AIF1, G1, IBA1

Molecular Weight: 17.7 kDa

UniProt: P55008

Pathways: Smooth Muscle Cell Migration