BACE2 Protein (His tag)
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- Target See all BACE2 Proteins
- BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))
- Protein Type
- Recombinant
- Biological Activity
- Active
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Origin
- Mouse
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Source
- HEK-293 Cells
- Purification tag / Conjugate
- This BACE2 protein is labelled with His tag.
- Purpose
- Recombinant Mouse BACE2/Beta secretase 2 Protein (His Tag)(Active)
- Sequence
- Met1-Pro462
- Characteristics
- A DNA sequence encoding the mouse BACE2 (Q9JL18) (Met1-Pro462) was expressed with a C-terminal polyhistidine tag.
- Purity
- > 95 % as determined by SDS-PAGE
- Endotoxin Level
- < 1.0 EU per μg of the protein as determined by the LAL method.
- Biological Activity Comment
- Measured by its ability to cleave a fluorogenic peptide substrate Mca-KPLGL-Dpa-AR-NH2 .The specific activity is >50 pmoles/min/μg.
- Top Product
- Discover our top product BACE2 Protein
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- Restrictions
- For Research Use only
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- Format
- Lyophilized
- Reconstitution
- Please refer to the printed manual for detailed information.
- Buffer
- Lyophilized from sterile PBS, pH 7.4
- Storage
- 4 °C,-20 °C,-80 °C
- Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- Target
- BACE2 (beta-Site APP-Cleaving Enzyme 2 (BACE2))
- Alternative Name
- BACE2/Beta secretase 2 (BACE2 Products)
- Synonyms
- AEPLC Protein, ALP56 Protein, ASP1 Protein, ASP21 Protein, BAE2 Protein, CEAP1 Protein, DRAP Protein, 1110059C24Rik Protein, AI850424 Protein, ARP1 Protein, CDA13 Protein, beta-site APP-cleaving enzyme 2 Protein, BACE2 Protein, Bace2 Protein
- Background
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Background: BACE2, also known as beta secretase 2, belongs to the peptidase A1 family. It is a protease known to be an important enzyme involved in the cellular pathways. BACE2 has been shown to interact with GGA1 and GGA2. It is the major β-secretase in vivo. BACE2 is located on chromosome 21 and may play a role in alzheimer's disease pathogenesis in down syndrome(DS). Overexpression of BACE2 by lentivirus markedly reduced amyloid β protein production in primary neurons. Despite an extra copy of the BACE2 gene in DS and the increase of its transcription, BACE2 protein levels are unchanged.
Synonym: 1110059C24Rik;AEPLC;AI850424;ALP56;ARP1;ASP21;BAE2;CDA13;CEAP1;DRAP
- Molecular Weight
- 49.2 kDa
- UniProt
- Q9JL18
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