CRADD Protein
Quick Overview for CRADD Protein (ABIN7319673)
Target
See all CRADD ProteinsProtein Type
Origin
Source
Purity
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Purpose
- Recombinant Human CRADD/RAIDD Protein
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Sequence
- Met1-Glu199
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Characteristics
- Recombinant Human CRADD is produced by our E.coli expression system and the target gene encoding Met1-Glu199 is expressed.
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Endotoxin Level
- < 1.0 EU per μg as determined by the LAL method.
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CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD) (AA 1-199) protein (His tag)
custom-made CRADD Origin: Human Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD) (AA 1-199) protein (His tag)custom-made CRADD Origin: Mouse Host: HEK-293 Cells Recombinant > 90 % as determined by Bis-Tris PAGE, anti-tag ELISA, Western Blot and analytical SEC (HPLC)
CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD) (AA 1-199) protein (GST tag)CRADD Origin: Human Host: Wheat germ Recombinant WB, ELISA, AA, AP
CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD) (AA 1-199), (full length) protein (His-SUMO Tag)CRADD Origin: Human Host: Escherichia coli (E. coli) Recombinant > 90 % SDS
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Restrictions
- For Research Use only
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Format
- Lyophilized
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Reconstitution
- Please refer to the printed manual for detailed information.
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Buffer
- Lyophilized from a 0.2 μm filtered solution of 20 mM PB,150 mM NaCl, pH 7.4.
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Storage
- 4 °C,-20 °C,-80 °C
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Storage Comment
- Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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- CRADD (CASP2 and RIPK1 Domain Containing Adaptor with Death Domain (CRADD))
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Alternative Name
- CRADD/RAIDD
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Background
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Background: Death Domain-Containing Protein CRADD (CRADD) is widely expressed in most tissues, with particularly high expression in the adult heart, testis, liver, skeletal muscle, fetal liver, and kidney. CRADD contains one CARD domain that mediates the interaction with caspase-2, and one death domain involved in the binding of RIP protein. CRADD functions as an apoptotic adaptor molecule specific for caspase-2 and FASL/TNF receptor-interacting protein RIP. CRADD induces cell apoptosis/cell death in numerous tissues. Defects in CRADD will result in mental retardation.
Synonym: Death Domain-Containing Protein CRADD, Caspase and RIP Adapter with Death Domain, RIP-Associated Protein with A Death Domain, CRADD, RAIDD
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Molecular Weight
- 23 kDa
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UniProt
- P78560
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Pathways
- Apoptosis, Caspase Cascade in Apoptosis, Positive Regulation of Endopeptidase Activity
Target
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